June 2025 in “CA A Cancer Journal for Clinicians” Among transgender men, this study reported a case of breast cancer found incidentally after a gender-affirming mastectomy, despite common lower breast cancer risks in this population, highlighting the importance of cancer screening and careful consideration of hormone therapy management in transgender and gender-diverse individuals.
25 citations
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June 2020 in “Dermatology practical & conceptual” This study reviewed treatments for chemotherapy-induced hair loss, finding that scalp cooling is FDA-approved for prevention, while minoxidil and bimatoprost may aid post-chemotherapy regrowth. The authors emphasized tailored therapies and the potential utility of tools like trichoscopy and trichogram.
21 citations
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September 2015 in “International journal of gynaecology and obstetrics” This article discusses safety, management, and adverse effects of chemotherapy in gynecological malignancies without reporting new clinical data, and emphasizes the importance of thorough patient and drug selection.
1 citations
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July 2025 in “Stem Cell Research & Therapy” In this study, researchers evaluated hair follicle transplantation techniques and reported that challenges such as limited follicle supply and low follicle survival rates often limit patient satisfaction, but advances in regenerative medicine may offer promising new solutions.
January 2025 in “Case Reports in Hematology” In this case report, a 17-year-old female with symptoms such as vaginal bleeding and weight loss was diagnosed with B-cell acute lymphoblastic leukemia, emphasizing the importance of considering hematological malignancies in young patients with unusual presentations, as early diagnosis can significantly improve outcomes.
278 citations
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May 2013 in “Ca” This review discusses the shift in toxicity profiles of cancer therapies from traditional chemotherapy to targeted agents, noting similar overall toxicities but with different side effects, and reports no new findings.
11 citations
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June 2012 in “Archives of Dermatological Research” This study demonstrated that high doses of L-cystine and vitamin B6 effectively prevent doxorubicin-induced hair loss in mice.
55 citations
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November 2004 in “Expert opinion on drug safety” This review describes the variety of mucocutaneous side effects caused by antineoplastic chemotherapy, with emphasis on skin, nails, and mucous membranes, while highlighting potential severity and the possibility of needing to adjust or interrupt treatment in rare cases; it presents no new clinical results.
August 2016 in “PolyPublie (École Polytechnique de Montréal)” This study observed early cardiac effects in young minipigs following high-dose doxorubicin chemotherapy, with a decrease in heart function and changes in cardiac MRI measurements compared to controls.
1461 citations
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March 2004 in “Annals of oncology” This study found that in first-line treatment of metastatic breast cancer, pegylated liposomal doxorubicin (PLD) provided similar progression-free survival to doxorubicin with significantly less cardiotoxicity.
81 citations
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February 2000 in “Anti-cancer drugs” In this pilot study, Doxil at 60 mg/m² every 4 weeks showed activity against hormone-refractory prostate cancer but was limited by severe mucocutaneous toxicities.
76 citations
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August 2007 in “Supportive care in cancer” The researchers reported that dermatological side effects from chemotherapy for women's cancers are common and significantly affect quality of life.
22 citations
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November 2005 in “BMC Cancer” This phase II study found that gemcitabine plus paclitaxel showed promising activity and manageable toxicity as first-line therapy for recurrent or metastatic breast cancer, with a 35% overall response rate.
3 citations
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February 2005 in “Journal of Quantitative Spectroscopy & Radiative Transfer/Journal of quantitative spectroscopy & radiative transfer” This study found that hair content of iron and zinc does not play a role in chemotherapy-induced alopecia in children with cancer.
May 2026 in “Research Square” In this study, the combination of scalp cooling therapy and a scalp lotion containing DHL-HisZnNa demonstrated a 91.3% hair recovery rate among breast cancer patients undergoing certain chemotherapy regimens, with no serious adverse events reported.
January 2026 in “Supportive Care in Cancer” This narrative systematic review reports that gel-based, cryogel, and silicone-based cooling caps offer cost-effective and environmentally sustainable alternatives to traditional machine-operated systems for preventing chemotherapy-induced hair loss, particularly benefiting low-income and low-resource settings.
September 2012 in “International Current Pharmaceutical Journal” In this study, CHOP chemotherapy for intermediate grade Non-Hodgkin's Lymphoma showed predictable toxicities but was generally well tolerated without treatment interruption among most patients.
44 citations
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November 2010 in “Current Opinion in Supportive and Palliative Care” This review discusses interventions for chemotherapy-induced hair loss and reports no new clinical results; scalp cooling and nutritional support are considered potential strategies but not yet substantiated.
2 citations
,
October 2016 This article discusses the range of skin-related side effects caused by chemotherapy and radiotherapy, including novel patterns emerging with targeted therapies, but does not report new clinical results.
June 2017 in “Journal of evolution of medical and dental sciences” This study observed that 21.6% of oncology patients experienced dermatological side effects from anti-cancer drugs, with hair loss and skin pigmentation changes being the most common.
This article provides a reference guide for various dermatological terms, treatments, and conditions, but reports no new clinical findings.
11 citations
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November 2021 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” This guideline reviews the diagnosis and treatment of malignant cutaneous angiosarcomas, highlighting the complexity of treatment and the importance of early detection despite non-specific clinical presentations.
69 citations
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February 2021 in “PLoS Computational Biology” This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.
68 citations
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May 2012 in “Annals of Oncology” This study reports that permanent and severe alopecia is a newly identified complication of the FEC 100–docetaxel regimen used for adjuvant breast cancer treatment.
62 citations
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February 2011 in “Expert review of dermatology” This review discusses the incidence, reversibility, and impact of chemotherapy-induced alopecia and concludes that scalp cooling is the most effective prevention method in most cases, though some questions remain.
38 citations
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September 2017 in “Oncologist” This source reports that scalp cooling is currently the only safe and FDA-cleared method to potentially reduce chemotherapy-induced hair loss, with about a 50% chance of maintaining sufficient hair to avoid needing a wig.
35 citations
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January 2004 in “European journal of oncology nursing” In patients undergoing treatment with capecitabine for colon cancer and metastatic breast cancer, this study observed that hand-foot syndrome occurred more frequently than with intravenous 5-FU, but other side effects were less common.
34 citations
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January 2018 in “International Journal of Dermatology” This review discusses chemotherapy-induced alopecia, highlighting its pathogenesis, clinical patterns, and current therapeutic approaches, with no new clinical results reported.
20 citations
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July 2013 in “PLoS ONE” This study found that inhibiting EGFR signaling in mice can prevent alopecia caused by cyclophosphamide treatment, highlighting its potential role in managing chemotherapy-induced hair loss.
19 citations
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November 2018 in “Nutrients” This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.