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    Glossary Androstenedione

    steroid hormone precursor to testosterone and estrogen

    Androstenedione, often referred to as Andro, is a steroid hormone that serves as a precursor in the biosynthesis of testosterone and estrogen. It is produced in the adrenal glands, ovaries, and testes, and plays a crucial role in the development of secondary sexual characteristics and reproductive function. Elevated levels of androstenedione can be associated with conditions like polycystic ovary syndrome (PCOS) and certain forms of adrenal hyperplasia.

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    1. Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone) The Journal of Clinical Endocrinology & Metabolism · 1975 · 96 citations
    2. Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS) Hormones · 2014 · 28 citations
    3. The influence of obesity on Androstenedione to Testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia Gynecological Endocrinology · 2011 · 15 citations
    4. Scalp hair 17‐hydroxyprogesterone and androstenedione as a long‐term therapy monitoring tool in congenital adrenal hyperplasia Clinical Endocrinology · 2016 · 9 citations
    5. Androstenedione Strength and Conditioning Journal · 1999
    6. A Model for Predicting Polycystic Ovary Syndrome Using Serum AMH, Menstrual Cycle Length, Body Mass Index and Serum Androstenedione in Chinese Reproductive Aged Population: A Retrospective Cohort Study Frontiers in Endocrinology · 2022 · 5 citations
    7. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    8. Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. Journal of Clinical Investigation · 1989 · 202 citations
    9. Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin 2001 · 196 citations
    10. SERUM STEROIDS AND PITUITARY HORMONES IN FEMALE PUBERTY: A PARTLY LONGITUDINAL STUDY Clinical Endocrinology · 1980 · 186 citations
    11. Gonadal Function Abnormalities in Sickle Cell Anemia Annals of Internal Medicine · 1976 · 163 citations
    12. Effects of Finasteride (MK-906), a 5<i>α</i>-Reductase Inhibitor, on Circulating Androgens in Male Volunteers* The Journal of Clinical Endocrinology and Metabolism · 1990 · 147 citations
    13. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women Fertility and sterility · 1985 · 142 citations
    14. LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair Clinical Endocrinology · 2015 · 134 citations
    15. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009 · 105 citations
    16. Effect of Leuprolide and Dexamethasone on Hair Growth and Hormone Levels in Hirsute Women: The Relative Importance of the Ovary and the Adrenal in the Pathogenesis of Hirsutism* The Journal of Clinical Endocrinology & Metabolism · 1990 · 100 citations
    17. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene 2002 · 94 citations
    18. Prevalence of polycystic ovaries in women with androgenic alopecia European journal of endocrinology · 2003 · 84 citations
    19. Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)∗ 1986 · 77 citations
    20. BENIGN PREMATURE ADRENARCHE: CLINICAL FEATURES AND SERUM STEROID LEVELS Acta Paediatrica · 1983 · 77 citations
    21. Treatment of hirsutism: comparisons between different antiandrogens with central and peripheral effects Fertility and sterility · 1999 · 75 citations
    22. Leuprolide and estrogen versus oral contraceptive pills for the treatment of hirsutism: a prospective randomized study. The Journal of Clinical Endocrinology & Metabolism · 1995 · 74 citations
    23. Ovarian Morphology Is a Marker of Heritable Biochemical Traits in Sisters with Polycystic Ovaries The Journal of Clinical Endocrinology and Metabolism · 2008 · 73 citations
    24. Physical Changes, Laboratory Parameters, and Bone Mineral Density During Testosterone Treatment in Adolescents with Gender Dysphoria ˜The œjournal of sexual medicine · 2019 · 71 citations
    25. Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study The Journal of Clinical Endocrinology and Metabolism · 2015 · 71 citations
    26. Clinical Usefulness of Plasma Androstanediol Glucuronide Measurements in Women with Idiopathic Hirsutism* 1987 · 66 citations
    27. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome Gynecological Endocrinology · 2009 · 64 citations
    28. THE TREATMENT OF HIRSUTISM WITH A COMBINATION OF DESOGESTREL AND ETHINYL OESTRADIOL Clinical endocrinology · 1985 · 64 citations
    29. Androgen metabolism in hirsute patients treated with cyproterone acetate 1984 · 64 citations
    30. Clinical, ultrasound and hormonal markers of androgenicity in acne vulgaris British Journal of Dermatology · 1995 · 57 citations