December 2024 in “American Journal of Case Reports” This case report highlights that insulin resistance in PCOS can occur even in underweight patients, as demonstrated by a 24-year-old woman who improved her menstrual cycle, acne, and hirsutism with metformin and dexamethasone over 6 months.
December 2024 in “Frontiers in Endocrinology” This research reviewed existing literature to explore treatment options for androgen-dependent diseases, reporting that among prostate cancer therapies analyzed, the drug olaparib as monotherapy resulted in longer survival compared to the combination of apalutamide and abiraterone, though combined treatment efficacy differences were not statistically significant.
October 2024 in “Journal of the Endocrine Society” This clinical case study reports on a postmenopausal woman experiencing hair loss and virilization symptoms, which were ultimately attributed to rare ovarian tumors identified after a bilateral salpingo-oophorectomy, despite normal imaging results.
October 2024 in “Journal of the Endocrine Society” This study examined a case of postmenopausal virilization in a woman and found that despite normal imaging, bilateral salpingo-oophorectomy revealed rare ovarian Leydig cell and Brenner tumors as the source of hyperandrogenism, with symptoms resolving post-surgery.
October 2024 in “Journal of the Endocrine Society” In this case report, the authors describe the diagnosis and management of a rare case of hyperandrogenism in a postmenopausal woman, attributed to coexisting ovarian Leydig cell and Brenner tumors, with improvement in symptoms following bilateral salpingo-oophorectomy.
October 2024 in “Journal of the Endocrine Society” In this case report, a 66-year-old postmenopausal woman with hyperandrogenism and alopecia underwent bilateral salpingo-oophorectomy, which revealed rare synchronous ovarian tumors causing virilization, highlighting the importance of surgical exploration despite normal imaging.
September 2024 in “Medicine theory and practice” In a clinical case study, researchers identified adrenocortical adenoma as the cause of hyperandrogenism syndrome in a preschool-aged girl, following a comprehensive diagnostic process and successful surgical intervention to remove the tumor, leading to positive clinical improvements.
September 2024 in “Pediatrics in Review” In this case review, researchers describe a 17-year-old transgender male experiencing clitoromegaly, hirsutism, and oligomenorrhea, investigating conditions like PCOS and non-prescription testosterone use for gender affirmation, and highlighting the importance of gender-affirming care to improve mental health outcomes.
August 2024 in “Archives of Women s Mental Health” This study found that women with PCOS exhibited higher levels of depression, tension induction, and impaired stress coping strategies compared to healthy controls, with these psychological issues correlating with hyperandrogenism but not with central obesity or insulin resistance.
July 2024 in “Journal of Investigative Dermatology” Skin hormone levels change significantly after menopause.
This report describes a complex case of postmenopausal hyperandrogenism with virilization and concurrent rare ovarian tumors, highlighting the critical role of interdisciplinary collaboration in diagnosing and managing such challenging scenarios.
February 2024 in “Biomedicines” This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.
This study found that androstenedione was more effective than testosterone in diagnosing hyperandrogenism in women with PCOS when measured by LC-MS/MS.
January 2024 in “Journal of the Endocrine Society” In this study, correlations between urinary and serum androgen metabolites were examined in girls aged 6-13, revealing that summed urinary metabolites strongly correspond with circulating androstenedione and testosterone levels, though individual variations depend on participant characteristics such as age and body measurements.
May 2023 in “Frontiers in Endocrinology” This study found that tildacerfont treatment in males with congenital adrenal hyperplasia reduced androgen levels and improved markers of testicular function, suggesting potential benefits for male reproductive health.
May 2023 in “Problems of Endocrinology” This study observed that "physiological" hyperandrogenism due to elevated total testosterone was associated with a 23.5% incidence of arterial hypertension, unlike hyperandrogenism due to elevated DHT levels.
November 2022 in “Journal of the Endocrine Society” This case study suggests that long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency, warranting further investigation.
November 2022 in “Journal of the Endocrine Society” This case study reports a rare instance of a virilizing androgen-only secreting adrenal cortical adenoma in a 13-year-old, with symptom resolution after surgical removal.
July 2022 in “Journal of Investigative Dermatology” This study developed a method to quantify hormones in skin secretions and found that hormonal composition varies by sex and anatomical site.
April 2022 in “Diabetes Therapy” In this case report, the researchers emphasize the importance of regular prostate exams and PSA tests for diabetic men, including those who are hypogonadal, because prostate cancer development is linked to intraprostatic dihydrotestosterone levels, not serum testosterone levels.
March 2022 in “VNU Journal of Science Medical and Pharmaceutical Sciences” This study developed a sensitive method using LC-ESI-MS/MS for accurate and reliable measurement of nine steroid hormones in children's serum.
September 2021 in “Research Square (Research Square)” This study found that measuring specific steroid hormone levels can aid in diagnosing P450 oxidoreductase deficiency, a subtype of congenital adrenal hyperplasia, by distinguishing affected patients from healthy individuals.
April 2021 in “Journal of evolution of medical and dental sciences” This study found that bioavailable testosterone and the free androgen index were significantly associated with various clinical and biochemical features of PCOS, including hirsutism, showing higher levels in PCOS patients compared to controls.
April 2020 in “Journal of the Endocrine Society” This case report describes a rare occurrence of giant bilateral adrenal myelolipomas in a 28-year-old female with CAH, emphasizing that large, hormonally active, or painful myelolipomas should be surgically removed.
April 2020 in “Journal of the Endocrine Society” This case report emphasizes the importance of early diagnosis of Swyer Syndrome in adolescents with slow pubertal progression and primary amenorrhea due to the high risk of germ cell cancers.
March 2020 in “Endocrinology research and practice.” In this study, treating prolactinoma with cabergoline normalized prolactin levels and affected some androgen-related parameters, but did not significantly improve hirsutism in affected women.
The case showed the need for quick investigation of virilization in women and how emotional health is linked to physical health.
September 2018 in “Fertility and Sterility” This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.
May 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study describes a postmenopausal woman's diagnosis with ovarian hyperthecosis, confirmed by a GnRHa test normalizing testosterone, highlighting hormone therapy as a therapeutic option when surgery is not feasible.
January 2014 in “edoc (University of Basel)” This research suggests that fluoxymesterone, an anabolic steroid, may inhibit a key enzyme, potentially contributing to cardiovascular issues by affecting cortisol's activation of mineralocorticoid receptors.