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    Glossary Androgen Signaling

    process where male hormones bind to cell receptors

    Androgen signaling refers to the process by which androgens, which are male hormones like testosterone, bind to specific receptors in cells to regulate various biological functions. This signaling pathway is crucial for the development and maintenance of male characteristics, but it also plays a role in conditions like androgenetic alopecia (pattern hair loss) by affecting hair follicle health and growth.

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    1. Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia. PubMed · 2025
    2. Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways InTech eBooks · 2017 · 1 citations
    3. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    4. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    5. Regulation of masculinization: androgen signalling for external genitalia development Nature Reviews Urology · 2018 · 45 citations
    6. Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia Archives of Dermatological Research · 2018 · 39 citations
    7. Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells Frontiers in Genetics · 2022 · 3 citations
    8. Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways British Journal of Dermatology · 2022 · 1 citations
    9. Xiaozhi Yufa decoction ameliorates androgenetic alopecia through inhibition of MAPK signaling and regulation of lipid metabolism Frontiers in Pharmacology · 2025
    10. Androgen Signaling in Sertoli Cells theses.fr (ABES) · 2014
    11. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    12. THE ROLE OF AGONISTS AND ANTAGONISTS OF THE WNT SIGNALING PATHWAY IN PATIENTS WITH ANDROGENIC ALOPECIA AND ALOPECIA AREATA Медико-фармацевтический журнал "Пульс" · 2021
    13. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    14. Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    15. Diet‐Induced Obesity Promotes Alopecia Through Oxidative Stress and Androgen Signalling in Female Mice Experimental Dermatology · 2026
    16. Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022 · 6 citations
    17. Androgen receptor signaling as a new target for intervention in acute myeloid leukemia Blood Advances · 2025
    18. Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells 2009 · 70 citations
    19. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015 · 46 citations
    20. Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology Journal of Investigative Dermatology · 2013 · 74 citations
    21. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways British Journal of Dermatology · 2017 · 27 citations
    22. Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway Journal of Dermatological Treatment · 2020 · 10 citations
    23. 453 Signaling by Senescent Melanocytes Induces New Hair Growth and Informs Hair Growth-Activating Injectable for Androgenetic Alopecia Journal of Investigative Dermatology · 2025
    24. Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway Stem Cell Research & Therapy · 2025
    25. Integrative Proteo‐Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1‐Mediated PPAR Signaling as a Potential Mediator Journal of Cosmetic Dermatology · 2024
    26. Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice Food frontiers · 2023
    27. 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation Journal of Investigative Dermatology · 2019
    28. Androgenetic alopecia: Identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology Faculty of Health; Institute of Health and Biomedical Innovation · 2013
    29. Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options Expert Opinion on Therapeutic Targets · 2019 · 19 citations
    30. An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia Cell Cycle · 2017 · 12 citations