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Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

New treatments for male hypogonadism are effective and should be personalized.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

SAHA syndrome is a condition in women involving skin and hair issues, often related to hormonal imbalances, and is treated based on the underlying cause.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

All three treatments reduce hirsutism, but spironolactone works best long-term.

Multiple treatments work best for hair loss.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

Certain drugs that block specific enzymes can help treat prostate diseases.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

Spironolactone plus finasteride reduces hirsutism more effectively.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.