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Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Testosterone is crucial for development, growth, and various body functions in mammals.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Treatments for common hair loss include minoxidil, finasteride, and hair transplantation.

Male hormones cause different growth in identical human hair follicles due to their unique epigenetic characteristics.

Baldness, especially at the front, may lower the risk of testicular cancer by 31%, but its link to prostate cancer is unclear.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Bald men may have a lower risk of testicular cancer.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.

COVID-19 may harm male fertility and damage the reproductive system.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Androgens, like testosterone, are crucial for early testicular descent in rats.

Androgenic Alopecia, a common hair loss condition, can be effectively treated with finasteride and other treatments.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

More research is needed to understand how testosterone is maintained in adult males.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.