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A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

The most common skin issues in females with Polycystic Ovary Syndrome (PCOS) are excessive hair growth, hair loss, oily skin, acne, dark skin patches, and skin tags, which may be linked to hormone and insulin levels.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

Insulin resistance increases the risk of developing type 2 diabetes and other health issues.

Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.

Understanding how acne develops in different diseases could lead to new treatments.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

A new method can almost perfectly distinguish adenomyosis from similar conditions using blood tests.

Baldness may lower the risk of testicular cancer.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

Higher DHT in male baldness may protect against prostate cancer.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Low testosterone might be a common cause of hair loss in male dogs.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Sorafenib helps some advanced cancers alone or with other treatments, but not all, and research continues to improve its use.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Family members of North Indian women with PCOS have a high rate of metabolic syndrome.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

The document says menstruation is important for women's health, discusses menstrual disorders, and suggests personalized treatment options.