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Active oxygen scavengers can reverse the suppression of hair cell growth caused by androgens.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

ERG increases SOX9, promoting prostate cancer growth and invasion.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.

Jagged1 and Epidermal Growth Factor together significantly increased hair growth in mice with androgen-suppressed hair.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.

Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Azelaic acid helps protect hair cells from UV damage and encourages hair growth by increasing certain gene expressions and proteins.

Shallot extract may help with hair growth and treating hair loss.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Finasteride helps reduce heart issues and improves heart function.

BLIMP1 is essential for skin maintenance but not for defining sebaceous gland progenitors.