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The document explains various skin conditions and their treatments.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Spironolactone use is not linked to an increased risk of breast cancer, but caution is advised for high-risk patients.

A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.

Certain skin diseases are linked to Agent Orange and similar chemicals; veterans should be screened and informed about uncertain risks, and current data doesn't link spironolactone with breast cancer.

Pubertal acne is linked to hormonal changes, affects quality of life, and is treated similarly to adult acne.

The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.

Men who start losing hair at 20 may have a higher chance of getting prostate cancer later.

Dr. Mario Lacouture recommends preventive and specific treatments for skin side effects caused by EGFR inhibitors to improve patients' quality of life.

Pregnancy can cause more body and scalp hair growth and make nails brittle, but these changes often revert after giving birth.

Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.

A woman's adrenal tumor disappeared after treatment with cyproterone acetate.

Some skin conditions are associated with other serious diseases, and office microscopy may miss many fungal infections.

Female pattern hair loss affects crown, increases with age, and has limited treatments.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

PCOS affects a similar percentage of Black and White women in the Southeastern United States.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

PCOS affects about 4% of women in the southeastern U.S. equally across Black and White populations.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.