research Response to Letter: Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss
Finasteride's sexual side effects not caused by androgen deficiency or SRD5A inhibition.
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research Depression, Higher Level of Tension Induction, and Impaired Coping Strategies in Response to Stress in Women with PCOS Correlate with Clinical and Laboratory Indices of Hyperandrogenism and Not with Central Obesity and Insulin Resistance
Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.
research Ability to Culture Dermal Papilla Cells from Red Deer Hair Follicles with Differing Hormonal Responses In Vivo Offers a New Model for Studying the Control of Hair Follicle Biology
Red deer hair cells offer a new way to study how hormones affect hair growth.
research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis
The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.
research Androgenetic Alopecia May Be Associated With Weaker COVID-19 T-Cell Immune Response: An Insight Into a Potential COVID-19 Vaccine Booster
Hair loss may link to weaker COVID-19 immunity, suggesting possible need for extra vaccine boost.
research Hyposecretion of the Adrenal Androgen Dehydroepiandrosterone Sulfate (DHEA-S) in the Majority of Alopecia Areata Patients: Is It a Primitive and Pathogenic Perturbation of the Hypothalamic-Pituitary-Adrenal Axis?
Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.
research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones
Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.
research The Hyperandrogenic-Insulin-Resistant Acanthosis Nigricans Syndrome: Therapeutic Response
Most patients improved with oral contraceptives, but some needed additional treatment.
research Hyperandrogenism and Menstrual Imbalance Are the Best Predictors of Metformin Response in PCOS Patients
High levels of male hormones and irregular periods best predict how well PCOS patients will respond to metformin treatment.
research Therapeutic Maintenance Effect of Finasteride 1 Mg Every Other Month Regimen in Androgenetic Alopecia: A Prospective Cohort Study
Taking finasteride every other month can still help with hair loss but may be less effective over time compared to taking it daily.
research The Stimulation of Hair Growth in the Flank Organs of Female Hamsters by Subcutaneous Testosterone Propionate and Its Inhibition by Topical Cyproterone Acetate: Dose-Response Studies
Testosterone increases hamster hair growth; cyproterone acetate reduces it.
research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells
Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
research Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators
Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.
research Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations
Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.
research Significance of the Polyglutamine Tract Polymorphism in the Androgen Receptor
The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.
research Hidradenitis Suppurativa: An Androgen-Dependent Disorder
Hidradenitis suppurativa improves with antiandrogen therapy.
research Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide
Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.
research Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase
Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.
research The Role of Androgen Therapy
Androgens, male hormones, play a role in both men and women's health, and testosterone therapy can help women with low levels, but it's not suitable for pregnant or lactating women, or those with certain conditions.
research Efficacy of Metformin Therapy in Adolescent Girls with Androgen Excess: Relation to Sex Hormone-Binding Globulin and Androgen Receptor Polymorphisms
Metformin works better for adolescent girls with PCOS who have certain genetic variations.
research What Does the Research Say About Androgen Use and Cerebrovascular Events?
Androgen use may increase the risk of stroke, but more research is needed.
research Novel Missense Mutation in the P-Box of Androgen Receptor in a Patient with Androgen Insensitivity Syndrome
A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.
research Detection of Membrane Androgen-Binding Site in Living Rat Prostate and Evaluation of Its Role in Prostate Blood Flow Regulation
The research found that androgens help control blood flow in the rat prostate through a specific binding site.
research Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome
Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.
research Hirsutography: Photographic Measurement of Linear Hair Growth in Hirsute Women During Comparison of Anti-Androgen Treatments
The photographic method accurately measures hair growth and both treatments effectively reduced hair growth in hirsute women.
research Clinical, Metabolic, and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, and Placebo-Controlled Trial
Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.
research Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia
Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.
research Co-Editors' Messages
Inflammation linked to the immune response may play a role in causing various types of hair loss.
research Regulatory Pathways Implicated in Male Androgenetic Alopecia Pathogenesis
Genes controlling hair growth and immune response are disrupted in male pattern baldness.
research Testosterone Target Therapy: Focus on Immune Response, Controversies, and Clinical Implications in Patients with COVID-19 Infection
Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.