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High DHEA and short cervical length in women with PCOS and recurrent miscarriages may harm pregnancy outcomes.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

More research is needed to understand how testosterone is maintained in adult males.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Omega-6 and LDL cholesterol increase the risk of hair loss.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Reproductive hormones play a crucial role in breast cancer development and treatment challenges.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.