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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

A woman with a rare adrenal tumor and hormonal disorder had improved testosterone levels after surgery, but her menstrual irregularities continued.

A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.