March 2023 in “Current Pharmaceutical Design” Spironolactone is effective for idiopathic hirsutism but has limited effects on other PCOS symptoms.
September 2022 in “Frontiers in Immunology” Anti-androgen therapy may boost immunity but increases injection site pain in vaccinated patients.
January 2020 in “Journal of clinical and cosmetic dermatology” A woman with hair loss regrew hair using minoxidil and spironolactone.
93 citations,
February 2009 in “Annals of the New York Academy of Sciences” 5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.
78 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
67 citations,
July 2006 in “Clinics in Dermatology” Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.
38 citations,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
30 citations,
August 2019 in “Medical Sciences” Androgens play a key role in causing PCOS (Polycystic Ovary Syndrome).
25 citations,
June 2017 in “Molecular and Cellular Endocrinology” Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.
25 citations,
November 1979 in “International Journal of Dermatology” Androgens affect skin conditions like acne and hair loss through specific biochemical pathways.
20 citations,
October 2017 in “Clinical Endocrinology” The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.
16 citations,
October 2007 in “Andrologia” DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.
9 citations,
August 2000 in “Journal of Periodontal Research” Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
9 citations,
December 1987 in “European journal of endocrinology” The treatment significantly reduced hair growth and male hormone levels in hirsute women.
5 citations,
September 1980 in “International Journal of Dermatology” Understanding hormones is key to treating certain skin conditions.
4 citations,
October 1988 in “Clinics in Dermatology” Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.
4 citations,
July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” Certain hormones can reduce skin oil and hair growth, potentially helping treat acne and excessive hair in women.
3 citations,
June 2016 in “Dermatology Reports” Finger length ratios don't predict baldness in men.
3 citations,
March 2016 in “Phytotherapy Research” The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.
2 citations,
March 2012 in “Nature Reviews Endocrinology” The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.
1 citations,
December 2022 in “Gynecological Endocrinology” The most common skin issues in females with Polycystic Ovary Syndrome (PCOS) are excessive hair growth, hair loss, oily skin, acne, dark skin patches, and skin tags, which may be linked to hormone and insulin levels.
January 2014 in “Medical Innovation of China” January 2011 in “The Chinese Journal of Dermatovenereology” 815 citations,
April 2010 in “The Journal of Clinical Endocrinology & Metabolism” Women with PCOS should be screened for heart disease risk and manage their health to prevent it.
53 citations,
May 1986 in “Clinics in endocrinology and metabolism” Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.
43 citations,
April 2011 in “AJP Endocrinology and Metabolism” This study found that the Odc1 gene, which encodes ornithine decarboxylase (ODC), was directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and played a role in myoblast proliferation and differentiation. Odc1 expression was significantly reduced in muscle from male muscle-specific AR knockout mice, indicating its regulation by AR. In vitro experiments showed that Odc1 expression was higher in proliferating myoblasts compared to differentiated myotubes, and dihydrotestosterone increased Odc1 levels in myoblasts. Inhibition of ODC activity reduced myoblast numbers, while overexpression of Odc1 increased cell numbers and delayed differentiation, as evidenced by reduced expression of differentiation markers. The study concluded that androgens upregulated Odc1 via the AR, promoting myoblast proliferation and delaying differentiation.
29 citations,
May 1988 in “Clinical Endocrinology” The document explored the use of fibroblasts as a model to study androgen-resistant states, focusing on conditions like androgen insensitivity syndrome. It highlighted the role of fibroblasts in understanding the molecular and cellular mechanisms underlying androgen resistance. The research provided insights into the genetic and biochemical aspects of androgen receptor function and its abnormalities, which could lead to conditions such as male pseudohermaphroditism. The study contributed to the broader understanding of how androgen resistance could manifest and be investigated at the cellular level, although specific details about the number of participants or experimental methods were not provided.
3 citations,
September 2016 in “Natural Product Communications” Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.
2 citations,
March 2000 in “CRC Press eBooks”