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A new pain-measuring system using sensors and AI can effectively detect pain in mice, which may help assess pain in humans and develop treatments.

Lecithin microemulsion safely delivers tetracaine hydrochloride through the skin.

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

Pregnancy reduces anxiety in rats, but finasteride reverses this effect.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Teak seed extract is safe and reduces pain in mice.

Negative expectations can cause adverse effects in dermatology treatments, like with finasteride for baldness, and careful communication can help reduce these nocebo responses.

Cedrus libani has potential medicinal uses but needs more safety studies.

Adiantum capillus extract reduces pain and swelling in animals.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

Asiasari radix extract may relieve certain types of pain by affecting GABA and NMDA receptors.

The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.

CBG may help with various medical conditions but needs more human research to confirm safety and effectiveness.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Eclipta alba has many health benefits and contains compounds with potential for drug development.

Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

Henna has potential health benefits and can treat various conditions, but more research is needed to confirm safety and effectiveness.

Some plant extracts may treat livestock diseases, certain animal treatments are safe and effective, but more research on drug safety and resistance is needed.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Cannabinoids may help treat various skin conditions.

Plumbagin may help protect cells, reduce inflammation, and has potential for treating various diseases, but more research is needed.

Lindera aggregata has many beneficial compounds that can help prevent and manage diseases.

Maxillariinae orchids contain 62 compounds with potential health benefits, including treating skin conditions and diseases like cancer and diabetes.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Tamarix aphylla may be effective for various medical conditions, but more research is needed to confirm its safety and effectiveness.

Finasteride didn't significantly improve ICPPS symptoms, more research needed.

Sorafenib is effective in treating Desmoid Tumor/Deep Fibromatosis.