17 citations
,
December 2001 in “Journal of Investigative Dermatology” This study found that osteopontin mRNA is abundantly expressed in dermal papilla cells during the catagen phase of hair growth in rats, suggesting a role in this phase.
17 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that Stat3 removal in keratinocytes of mice impairs healing and disrupts the normal hair cycle, leading to skin ulcers and hair loss as they age.
17 citations
,
June 1997 in “Baillière's clinical obstetrics and gynaecology” This review explores recent findings on the regulation of the pilosebaceous unit and reports no new clinical results, emphasizing the emerging understanding of growth factors and steroid hormones in hair growth processes.
16 citations
,
October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
16 citations
,
April 1998 in “Journal of Investigative Dermatology” ACTH promotes hair growth in mink, but α-MSH does not.
16 citations
,
April 2021 in “International Journal of Molecular Sciences” This study found that micro-current electrical stimulation may promote hair growth in human hair follicle-derived papilla cells and a mice model by enhancing cell proliferation, migration, and activating key growth pathways.
16 citations
,
October 2020 in “Lipids in Health and Disease” This review explores the current understanding of leptin's role in psoriasis and other skin diseases but reports no new clinical findings, emphasizing that the exact mechanisms of its impact are still being investigated.
16 citations
,
October 2019 in “Biological & Pharmaceutical Bulletin” This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.
16 citations
,
July 2019 in “Biochemical and Biophysical Research Communications” This study concluded that CD36-expressing dermal sheath cells may influence the modulation of blood capillaries in hair follicles, potentially affecting hair cycling.
16 citations
,
March 2019 in “Experimental dermatology” This study found that injury affects the behavior of hair follicle dermal stem cells, steering them towards recruitment into the dermal papilla, a shift influenced by the hair cycle stage.
16 citations
,
July 2016 in “Journal of Dermatological Science” This study found that stable regeneration of pigmented hairs in mice after severe wounding can occur when the wound is made during the anagen stage, influenced by Wnt and Kit signaling pathways.
16 citations
,
April 2015 in “Lasers in Surgery and Medicine” In this study, the researchers found that the effectiveness of a 1,550-nm fractional laser in promoting hair growth in mice depends on the specific combination of beam energy and density, with inappropriate settings potentially causing ulcers or hair follicle injury.
16 citations
,
August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.
16 citations
,
January 2012 in “Asian pacific Journal of Tropical Biomedicine” This study found that a 2% polyherbal phyto-complex cream containing aqueous extracts of Trichosanthes cucumerina and Abrus precatorius effectively promoted hair growth in preclinical tests, comparable to minoxidil 2%.
16 citations
,
April 2007 in “Journal of Medical Primatology” This study reports that a 14-year-old female rhesus monkey with alopecia universalis was found to have a T-cell-mediated autoimmune disease similar to human alopecia areata universalis.
16 citations
,
November 2005 in “Journal of Clinical Pathology” This study found that CD1d is strongly expressed in human scalp skin and hair follicles, particularly in the anagen phase, suggesting a role in scalp immunology and potential implications for hair disorder treatment.
16 citations
,
August 1989 in “PubMed” This study concluded that high-dose oral therapy with L-cystine, gelatin, and vitamin A significantly improved hair growth indicators in patients with diffuse hair loss, with no systemic side effects observed.
16 citations
,
August 1967 in “JAMA” This study reports that diffuse alopecia of the scalp developed in some women during or after using oral contraceptive drugs, suggesting a potential link between the medication and hair loss.
15 citations
,
October 1999 in “British Journal of Dermatology” This study found that collagen remodeling is more active in anagen-stage skin than in telogen-stage skin in mice, suggesting that collagen modifications may support hair follicle growth and migration.
15 citations
,
July 2016 in “Biochemical Journal” This study found that Wnt ligands from CD133-positive dermal papilla cells are essential for maintaining hair growth by supporting cell signaling between different hair follicle structures.
15 citations
,
February 2015 in “Cell & tissue research/Cell and tissue research” This review examines the role of P-cadherin in skin and hair biology, emphasizing its importance in human hair growth, cycling, and pigmentation, and reports no new research findings.
15 citations
,
May 2013 in “American Journal of Medical Genetics - Part A” People with X-linked hypohidrotic ectodermal dysplasia have no sweat ducts and less, thinner hair.
15 citations
,
September 2012 in “PTR. Phytotherapy research/Phytotherapy research” In this study, topical application of ginsenosides Rb₁ and Rd in mice increased cell proliferation in hair follicles, suggesting they may help prevent hair loss by promoting growth through p63 induction.
15 citations
,
January 2009 in “Journal of chemical and pharmaceutical research” This study found that a herbal hair oil formulation with 7.5% concentration of each active ingredient, prepared using the boiling method, showed excellent hair growth activity comparable to 2% minoxidil.
15 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review discusses the role of hair microscopy in diagnosing alopecia, stating that while it excludes diagnoses related to hair breakage, it only confirms nonspecific short anagen in alopecia cases.
15 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” In a C3H mouse model, this study found that topical retinoids can significantly alter hair-cycle dynamics by prolonging the anagen phase and shortening the telogen phase, a reaction connected to increased cellular retinoic acid-binding protein levels.
14 citations
,
May 2020 in “Archiv für Tierzucht” This study found that genes such as FGF5, FGFR1, and RRAS may impact the growth cycle of secondary hair follicles in Inner Mongolian Cashmere goats.
14 citations
,
May 2017 in “InTech eBooks” This chapter reviews the anatomy and physiology of hair follicles but reports no new research findings or clinical results.
14 citations
,
March 2016 in “Mechanisms of Development” This study found that BNC2 is critical for hair follicle regeneration and other developmental processes, as Bnc2−/− mice exhibit incomplete hair follicle development and developmental defects, and BNC1 cannot substitute for BNC2.
14 citations
,
February 2011 in “Experimental dermatology” This study identifies cartilage oligomeric matrix protein (COMP) as a key extracellular matrix component in human hair follicle cycling, potentially regulated by TGFβ signaling, and suggests its importance in normal hair follicle biology.