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    Glossary Anagen Phase

    active period of hair growth in the hair cycle

    The Anagen Phase, also known as the growth phase, is the active period of hair growth in the hair cycle. During this phase, hair follicles are actively producing new hair cells, leading to the elongation of the hair shaft. This phase can last anywhere from 2 to 7 years, depending on genetic factors, and determines the maximum length of the hair.

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    1. PDGF isoforms induce and maintain anagen phase of murine hair follicles Journal of Dermatological Science · 2006 · 136 citations
    2. De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle Journal of Investigative Dermatology · 2010 · 41 citations
    3. Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep PLoS ONE · 2013 · 37 citations
    4. Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair Experimental Dermatology · 2014 · 30 citations
    5. Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells Pharmaceutics · 2021 · 28 citations
    6. Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles International Journal of Molecular Medicine · 2011 · 28 citations
    7. Histochemistry of the human hair follicle with consideration of anagen phases I to VI Acta Histochemica · 1992 · 18 citations
    8. Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells BMC complementary medicine and therapies · 2020 · 15 citations
    9. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles Pharmacological Reports · 2017 · 14 citations
    10. The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered <i>Hoxc</i> gene expression in the ears Veterinary Dermatology · 2008 · 10 citations
    11. A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study Dermatology practical & conceptual · 2017 · 8 citations
    12. <i>Eclipta prostrata</i> promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5 Pharmaceutical Biology · 2019 · 7 citations
    13. Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice International Journal of Radiation Biology · 2013 · 6 citations
    14. Effect of <i>Plantago asiatica L</i>. extract on the anagen phase in human hair follicle dermal papilla cells Journal of Cosmetic Dermatology · 2023 · 5 citations
    15. Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase Frontiers in Cell and Developmental Biology · 2022 · 5 citations
    16. CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis Journal of Dietary Supplements · 2014 · 3 citations
    17. Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006 EFSA Journal · 2011 · 1 citations
    18. Effect of Escin in Human Hair Follicular Organ Culture: Prolonged Anagen Phase Chonnam Medical Journal · 2026
    19. Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling Journal of Microbiology and Biotechnology · 2025
    20. Hair growth-promoting effects of Stellera chamaejasme L. extract on C57BL/6 mice via induction of anagen phase genes Journal of Traditional Chinese Medical Sciences · 2025
    21. Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial MEDS Public Health and Preventive Medicine · 2025
    22. 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase Biological and Pharmaceutical Bulletin · 2024
    23. Pilose antler extract promotes hair growth in androgenic alopecia mice by promoting the initial anagen phase Biomedicine & pharmacotherapy · 2024
    24. The Effect of Umbraulva japonica on the Stimulation of Anagen Phase Yaghag hoeji · 2023
    25. 1103 Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin 2023
    26. 586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase Journal of Investigative Dermatology · 2022
    27. ESDR586 - Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase 2022
    28. 575 An extract of Leontopodium alpinum prolongs anagen phase in human hair follicles ex vivo Journal of Investigative Dermatology · 2021
    29. Effects of Trichosolandtrade; on Increasing the Anagen Phase of the Capillary Cycle of Volunteers 2019
    30. A topical botanical lotion increases and remodels scalp collagen content through longer anagen phase, opening new perspectives Journal of The American Academy of Dermatology · 2016