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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Dutasteride caused more penile tissue changes than finasteride, possibly increasing erectile dysfunction risk.

Oregano extract helps fix testis and sperm damage caused by finasteride.

Dutasteride and finasteride have similar risk for osteoporosis and fractures in older men.

Certain foods and supplements can help treat skin diseases alongside medication.

Health warnings and public health actions led to a significant drop in flutamide prescriptions for women, but off-label use still continues.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

New oral treatment, finasteride, effectively and safely treats common hair loss.

Dihydrotestosterone changes some hormone-related gene expressions in rat pituitary glands but doesn't affect the estrous cycle.

Androgen levels can increase at any age, affecting symptoms like acne, hair loss, and prostate size.

Endocrine disruptors may cause early hair loss.

Finasteride worsens heart damage but reduces cell toxicity caused by nandrolone decanoate.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

5α-reductase inhibitors help shrink the prostate, improve urinary symptoms, and may reduce prostate cancer risk.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Cyproterone slightly inhibited hair growth in castrated mice, while tamoxifen significantly inhibited hair growth in castrated mice but not in normal mice.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Levothyroxine is less effective in men with early-onset male-pattern baldness.

Teak leaf extract may effectively and safely promote hair growth in males with androgenic alopecia.

Chromosomal differences affect how muscle cells respond to testosterone.