47 citations
,
April 2003 in “Journal of dermatological science” This study showed that Thujae occidentalis semen extract inhibited 5alpha-reductase type 2 in laboratory tests and reduced androgen-related hair loss in animal models, suggesting potential use for male pattern baldness.
47 citations
,
July 1997 in “British Journal of Dermatology” This research observed that during the catagen phase, the inner root sheath of hair follicles becomes an early target, highlighting its potential role in maintaining hair follicle homeostasis.
46 citations
,
August 2019 in “Journal of the European Academy of Dermatology and Venereology” This study found that patients with alopecia areata reported worse quality of life and higher anxiety and depression levels compared to those with androgenetic alopecia and healthy controls.
46 citations
,
August 2019 in “Journal of Ethnopharmacology” This review compiles current information about Eclipta prostrata, traditional uses, and its promising pharmacological properties, like hepatoprotective and anti-inflammatory effects, but emphasizes that more research is needed to fully understand its mechanisms and ensure safety for clinical application.
46 citations
,
January 2008 in “Journal of cosmetic dermatology” Caffeine and siloxanetriol alginate caffeine in emulsion form can reduce fatty cell size and number, potentially treating cellulite effectively.
46 citations
,
December 1992 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study, researchers observed that testicular 17β-hydroxysteroid dehydrogenase deficiency in an inbred Arab population in Israel leads to genital ambiguity at birth and progressive virilization after puberty.
46 citations
,
March 2019 in “Journal of Pineal Research” The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.
46 citations
,
September 2018 in “Expert Opinion on Drug Delivery” This study reported that nanostructured lipid carriers with melatonin improved hair density and decreased hair loss in patients with androgenic alopecia, suggesting a promising direction for future treatments.
46 citations
,
May 2018 in “Dermatologic Surgery” In this study, subdermal platelet-rich plasma injections significantly increased hair count and shaft caliber in individuals with androgenetic alopecia, with monthly treatments potentially offering greater benefits.
46 citations
,
April 2016 in “Journal of Investigative Dermatology” This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.
46 citations
,
June 2015 in “Journal of Investigative Dermatology” This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.
46 citations
,
December 2014 in “Epilepsy & behavior” This study found that weight gain and alopecia were the most common cosmetic side effects of AEDs, with valproic acid and pregabalin being particularly associated with these effects.
46 citations
,
April 2014 in “PLOS ONE” This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.
46 citations
,
October 2012 in “Seminars in reproductive medicine” This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.
46 citations
,
September 2010 in “Veterinary Dermatology” This retrospective study documented various skin diseases in alpacas, reporting bacterial infections as the most common, along with other conditions described for the first time.
46 citations
,
September 2003 in “International Journal of Dermatology” This study found that trichodynia is common among patients with telogen effluvium and androgenetic alopecia, and it often coexists with psychological issues like depression and anxiety.
46 citations
,
September 2002 in “Journal of the European Academy of Dermatology and Venereology” In this study, depression was more common among women with androgenetic alopecia, while men showed higher levels of anxiety, aggressiveness, and a lack of adherence to treatment.
46 citations
,
January 1991 in “Journal of Investigative Dermatology” Minoxidil works in liver and outer hair root sheath for hair growth.
45 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article reviews factors affecting follicular unit extraction, emphasizing the need to tailor procedures to individual patient characteristics, but reports no new experimental findings.
45 citations
,
May 2012 in “CRC Press eBooks” The book helps doctors better understand and treat hair disorders due to gaps in their training.
45 citations
,
May 2022 in “Biomedicines” This review discusses using human follicular fluid in metabolomic analysis as a diagnostic tool and predictor of success in assisted reproductive technology for PCOS patients, reporting no new results.
45 citations
,
March 2020 in “ACS Applied Materials & Interfaces” In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.
45 citations
,
August 2019 in “Dermatologic Therapy” This review discusses the physiopathology of androgenetic alopecia and evaluates various traditional and emerging treatments, reporting no new clinical results but highlighting the need for enhanced treatment strategies.
45 citations
,
December 2018 in “Lasers in Medical Science” In a 24-week randomized trial, this study found that the RAMACAP laser helmet significantly increased hair density and diameter in androgenetic alopecia patients compared to a sham device, although limitations included a small sample size and potential issues with the control used.
45 citations
,
September 2018 in “International Journal of Women's Dermatology” This review discusses the use of platelet-rich plasma as a treatment for androgenetic alopecia and highlights the need for standardized protocols, reporting no new clinical results.
45 citations
,
November 2012 This review discusses the association between androgen receptor gene polymorphism and PCOS, reporting mixed findings on whether shorter or longer CAG repeats are linked to the disorder; it provides no new results and calls for further studies.
45 citations
,
January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.
45 citations
,
August 2009 in “American Journal Of Pathology” Noggin promotes skin tumors by activating certain cell signaling pathways.
45 citations
,
August 2005 in “Bioorganic & medicinal chemistry” This study found that novel androgen antagonists incorporating a carborane moiety showed anti-androgenic activity comparable to flutamide in a laboratory setting.
45 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses various in vitro and in vivo models for studying hair follicle function, noting their potential in developing new treatments for hair disorders but reports no new results.