71 citations
,
June 2005 in “Journal of Investigative Dermatology” This study demonstrates that PAD1 and PAD3 are involved in hair follicle differentiation, while PAD1 and PAD2 may play a role in the physiology of sweat glands and arrector pili muscles.
70 citations
,
August 2020 in “Nanomaterials” This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.
70 citations
,
July 2020 in “Pharmacological Reports” This review discusses the antiviral potential of cepharanthine against SARS-CoV-2, noting its effectiveness in preclinical models but presenting no new clinical results.
70 citations
,
April 2017 in “Lasers in surgery and medicine” This study found that blue light at a wavelength of 453 nm promoted hair growth ex vivo, potentially through interacting with OPN3 receptors in human hair follicles.
70 citations
,
April 2013 in “Endocrine” This review found that lifestyle changes, such as diet and exercise, are beneficial for managing metabolic and endocrine abnormalities in obese patients with PCOS and suggests combining these with anti-obesity agents for enhanced effects.
70 citations
,
January 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study explored the interaction between androgen and Wnt signaling in dermal papilla cells, targeting the effects of androgen on hair growth reduction.
70 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This study reports that the TrichoScan method effectively measures hair growth parameters and detected significant improvements in hair counts and thickness in men with androgenetic alopecia after finasteride treatment.
70 citations
,
February 2012 in “Human Reproduction” This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.
70 citations
,
July 2005 in “Journal of Ethnopharmacology” In this study, Ganoderma lucidum extract was found to significantly inhibit 5alpha-reductase activity and testosterone-induced prostate growth in rats, suggesting potential use for treating benign prostatic hyperplasia.
70 citations
,
April 1990 in “Journal of The American Academy of Dermatology” Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.
69 citations
,
October 2014 in “PubMed” This article reviews the various uses and chemical constituents of Rosmarinus officinalis, a common herb used for conditions affecting multiple bodily systems, but presents no new experimental findings.
69 citations
,
January 2021 in “Journal of Biological Chemistry” This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.
69 citations
,
April 2019 in “Biomedicines” This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.
69 citations
,
April 2017 in “BMJ open” This study found that people with alopecia who worry about not wearing a wig reported higher levels of depression, anxiety, and social anxiety, although wig use increased social confidence for many.
69 citations
,
May 1997 in “Veterinary Pathology” This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.
69 citations
,
September 1991 in “Journal of Surgical Research” This review highlights the unique scarless wound healing abilities of fetuses and discusses potential applications to adult wound healing, reporting no new experimental findings.
69 citations
,
February 2019 in “Industrial Crops and Products” Zizyphus lotus leaves and fruits have strong antidiabetic effects and potential skin benefits.
69 citations
,
September 2013 in “American Journal of Alzheimer s Disease & Other Dementias®” This study found that a new peptide, Snakin-Z, from Ziziphus jujuba fruits, shows significant inhibitory effects on AChE and BChE enzymes and strong antioxidant activity, suggesting potential benefits for Alzheimer's disease treatment.
69 citations
,
April 2010 in “British Journal of Dermatology” This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.
69 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review discusses rodent models of alopecia areata and highlights genetic and epigenetic factors influencing its development, but reports no new experimental results.
69 citations
,
August 1995 in “Annals of Plastic Surgery” This study showed that ultrapulse carbon dioxide laser ablation can precisely remove rabbit skin without scarring, facilitating normal skin and hair restoration within one month.
68 citations
,
May 2021 in “Endocrine” This review discusses the emerging "endocrine phenotype" of COVID-19, highlighting the implications for managing diabetes, obesity, vitamin D deficiency, and other endocrine conditions in affected patients.
68 citations
,
April 2014 in “Journal of Molecular Endocrinology” This review summarizes existing knowledge on androgen receptor activity in breast cancer and reports no new clinical findings, with emphasis on therapies targeting androgen signaling in specific BC subtypes.
68 citations
,
April 2002 in “Journal of Alternative and Complementary Medicine” This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.
68 citations
,
November 2015 in “The Journal of Allergy and Clinical Immunology” In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.
68 citations
,
May 2015 in “Indian Journal of Dermatology” This case series found that adding microneedling to conventional finasteride and minoxidil therapy for androgenetic alopecia improved new hair growth and patient satisfaction in poor responders.
67 citations
,
March 2018 in “The Journal of Clinical Endocrinology & Metabolism” This study reported that estrogen-progestin oral contraceptives, antiandrogens, and insulin sensitizers are more effective than placebo in treating hirsutism in women, with combination therapies generally proving superior to monotherapy.
67 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the causes, associated conditions, and treatment options for alopecia areata, such as corticosteroids and wigs, but reports no new clinical findings.
67 citations
,
July 2006 in “Clinics in Dermatology” This review discusses the dermatologic manifestations of hyperandrogenism in women and outlines the diagnostic approach and treatment options, reporting no new clinical results.
67 citations
,
December 2009 in “International Journal of Dermatology” This study suggests that hormonal receptor activity in skin regions undergoing mechanical stretching may influence extracellular matrix metabolism and the formation of SD, with variations in receptor functionality throughout lesion development stages.