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This study found that wedelolactone from Eclipta prostrata L. significantly reduced lung inflammation and fibrosis in mice with bleomycin-induced pulmonary fibrosis, suggesting potential therapeutic benefits through AMPK activation.

This review covers the molecular basis of Birt–Hogg–Dubé syndrome and its implications for potential therapeutic targets, but it does not report new experimental results.

This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.

This study found that miR-432 inhibits KRT83 expression, revealing potential molecular mechanisms for the formation of curly fleece in Tan sheep and suggesting implications for understanding curly hair formation in humans.

This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels.

This review highlights the role of disrupted glycolysis in exacerbating reproductive and metabolic abnormalities in PCOS and suggests that agents like metformin and resveratrol may help restore glycolytic balance and improve ovarian function.

This study identified a wide range of differentially expressed lncRNAs and mRNAs in the hair follicles of Hetian sheep, which may be useful for further research on improving carpet wool quality.

Metabolic issues may trigger lymphocytic cicatricial alopecia, and treatments targeting these issues could help.

This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.

In this study, researchers developed a near-infrared-responsive nanoplatform that synergistically enhances chronic wound healing by accelerating mitochondrial restoration and immune modulation, leading to enhanced wound repair and high-quality healing in diabetic rat models.

In this systematic review, various nutrients and diets, such as a plant-based diet and supplements like omega-3 fatty acids, were found to impact tissue regeneration, skin health, and wound healing, highlighting the role of nutrient-sensitive signaling pathways in these processes.

This study found that subcutaneous adipose tissue-derived extracellular vesicles (AT-EVs) protect skin from photodamage by enhancing fibroblast proliferation and reducing oxidative stress compared to those from adipose-derived stem cells.

In this study, the combination of two compounds activated AMPK levels in skin cells, reducing oxidative damage and improving energy production, which may support faster recovery and repair in aging skin.

This research found that metformin promoted hair growth in vitro by activating the AMPK/β-catenin signaling pathway in dermal papilla and outer root sheath cells.

This study identified that α-ketobutyrate (α-KB) extends lifespan and improves health markers in Caenorhabditis elegans and aged mice by modulating pyruvate metabolism and activating AMPK pathways, with potential implications for human anti-aging treatments.

In this study, researchers found that estrogens activate and androgens inhibit brown adipose tissue thermogenesis via the VMH, affecting energy balance and suggesting targets for treating cachexia and obesity.

In this narrative review, researchers synthesized current evidence on topical metformin's potential benefits for various skin conditions, citing primarily preclinical studies that highlight its anti-inflammatory, antioxidant, and regenerative properties, although clinical translation requires further rigorous trials.

In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.

This study revealed that metformin, beyond its hypoglycemic use, may have potential reuse in treating obesity, cardio-cerebrovascular diseases, and more, including possible future applications for Alzheimer's and other conditions.

This study reports that hair regeneration can be stimulated by small molecules like α-ketoglutarate, α-ketobutyrate, rapamycin, and metformin, which activate autophagy pathways.

This review of preclinical studies suggests that topical metformin could aid diabetic wound healing via multiple pathways, but emphasizes the need for further clinical trials to confirm its safety and efficacy.

This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.

This study demonstrated that Forsythiaside A protected against oxidative stress in both cell models and a mouse model of liver damage, suggesting its potential as a liver-protective agent.

This review examines the antitumor effects of metformin and highlights discrepancies between basic and clinical study results, noting that these may be due to different dosing levels.

This study found that dapagliflozin enhanced mitochondrial quality control and adaptive autophagy in human cardiomyocytes under hypoxic stress, suggesting that these mechanisms may contribute to the cardioprotective effects of sodium-glucose cotransporter 2 inhibitors in ischemic injury.

This review discusses the pharmacological actions and potential therapeutic benefits of ginsenoside compound K for metabolic disorders, reports no new clinical results, and suggests further research on its bioavailability and toxicity.

This study investigated pyranoanthocyanin Vitisin A and found it significantly lowered triglyceride levels and reduced body weight in high-fat diet-fed mice, outperforming Cyanidin-3-O-glucoside by inhibiting hepatic lipogenesis and enhancing fatty acid β-oxidation.

This review discusses the pharmacology and potential therapeutic effects of rare ginsenoside compound K on metabolic disorders but presents no new clinical results, highlighting the need for further studies on its bioavailability and toxicity.

This scoping review revealed that topical metformin shows potential in dermatology, displaying anti-inflammatory, antioxidant, anti-photoaging, wound-healing, and antitumor properties, while also being effective for conditions like melasma and acne vulgaris; further clinical trials are needed to confirm its safety and efficacy for long-term human use.

This review compiles current knowledge of Eclipta prostrata's botanical details, ethnomedical uses, phytochemical components, and various pharmacological activities, emphasizing its potential for modern pharmaceutical formulations based on its anti-inflammatory, antioxidant, anticancer, and other therapeutic properties.