83 citations
,
October 1998 in “The American Journal of Human Genetics” A specific gene mutation causes complete hair loss in an Irish Traveller family.
83 citations
,
December 2004 in “American Journal of Obstetrics and Gynecology” 78 citations
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May 2012 in “Journal of Investigative Dermatology” A specific gene mutation causes woolly hair and hair loss.
78 citations
,
November 2008 in “Fertility and Sterility” Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.
76 citations
,
November 2010 in “Journal of The American Academy of Dermatology” In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.
76 citations
,
December 2011 in “Journal of Cell Science” This study found that keratins have evolutionarily conserved and domain-selectively enriched amino acids, which likely reflect their unique structural roles, with distinct patterns observed among epidermal, hair, and simple-type epithelial keratins.
75 citations
,
January 1995 in “American journal of primatology” In this study, seasonal hair loss was most pronounced in low-ranking male vervet monkeys, and changes in scrotal color and hyperpigmentation also correlated with hair loss, but underlying causes were not identified.
75 citations
,
November 2007 in “Clinical endocrinology” This study found that several drugs, including flutamide and spironolactone, significantly reduced hirsutism in women, with reduced effectiveness in those with higher BMI.
73 citations
,
June 2010 in “PLoS Genetics” This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.
72 citations
,
December 2009 in “Organic and Biomolecular Chemistry” This study describes Hg(OTf)2 as a new and efficient catalyst for various organic synthesis reactions, including alkyne hydration and C–C bond forming cyclizations.
72 citations
,
December 1996 in “Journal of Investigative Dermatology” This study observed that human hair follicles were able to regenerate fiber-forming structures after the bulb was amputated and transplanted onto athymic mice, suggesting a general regenerative capacity.
69 citations
,
January 2021 in “Journal of Biological Chemistry” This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.
68 citations
,
February 2019 in “Urology” Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.
65 citations
,
May 2001 in “Journal of Analytical Toxicology” This study found that amphetamine was preferentially incorporated into black hair compared to white hair in Long-Evans rats, suggesting a role for drug basicity in hair color-based drug incorporation.
65 citations
,
April 1999 in “Journal of Parasitology” This study found that all lesions in mice treated with a new topical formulation, WR 279,396, healed completely without relapse, outperforming other formulations and showing no toxicity.
64 citations
,
May 2003 in “Journal of health psychology” This study found that women with PCOS reported higher overall psychological distress, but there was no significant link between their perceived hirsutism and this distress.
62 citations
,
June 2023 in “Acta Dermato Venereologica” This observational study found that patients with various skin diseases across 17 European countries experience higher levels of perceived stigmatization than skin-healthy controls, particularly those with psoriasis, atopic dermatitis, alopecia, and bullous disorders, with factors such as disease severity and psychological distress influencing stigmatization levels.
62 citations
,
July 2013 in “American Journal of Clinical Dermatology” This study found that alopecia areata patients had higher oxidative stress and lipid peroxidation levels than healthy controls, suggesting potential involvement in the disease's pathogenesis.
62 citations
,
September 1974 in “Academy of Management Journal” This article discusses the need for organizational scholars to shift focus from big business organizations to everyday events and places, but it reports no new empirical results.
60 citations
,
August 2008 in “Human molecular genetics online/Human molecular genetics” This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.
56 citations
,
September 2013 in “Experimental Dermatology” This guide reviews the biology of sebaceous glands and their evaluation methods, emphasizing their roles beyond lipid production in skin health and disease, and reports no new research results.
54 citations
,
June 2023 in “International Journal of Molecular Sciences” This review reports that myricetin, a naturally occurring antioxidant in plants, may assist in cancer management by enhancing the effects of existing drugs and inhibiting inflammatory markers, based on in vivo and in vitro studies.
53 citations
,
February 2022 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This review discusses the use of antimüllerian hormone as a marker of ovarian reserve in infertility diagnosis and treatment, noting it reflects oocyte quantity but not health or pregnancy likelihood.
49 citations
,
March 2014 in “Journal of Investigative Dermatology” This study demonstrated that combining AMD3100 with low-dose tacrolimus in a stem cell mobilization approach significantly reduced wound healing time and improved scar and hair follicle regeneration in full-thickness skin wounds.
46 citations
,
August 2019 in “Journal of Ethnopharmacology” This review compiles current information about Eclipta prostrata, traditional uses, and its promising pharmacological properties, like hepatoprotective and anti-inflammatory effects, but emphasizes that more research is needed to fully understand its mechanisms and ensure safety for clinical application.
46 citations
,
July 1974 in “The Journal of Clinical Endocrinology & Metabolism” In this study, women with hirsutism and amenorrhea showed lower serum estradiol and sex hormone binding globulin concentrations but higher levels of unbound testosterone compared to normal individuals.
44 citations
,
March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
42 citations
,
June 2021 in “Pharmaceutics” This review summarizes the use of 3D printing technologies for creating microneedles and evaluates their associated benefits, challenges, and regulatory considerations, but does not present new experimental results.
41 citations
,
March 2017 in “PLoS neglected tropical diseases” This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.
40 citations
,
December 2016 in “Journal of Ovarian Research” In this study on rats, rutin showed dose-dependent improvements in hormonal, antioxidant, and lipid profiles related to polycystic ovary syndrome, with effects comparable to metformin.