12 citations,
February 2010 in “Asian Journal of Animal and Veterinary Advances” Young and adult hamsters both respond similarly to testosterone and finasteride treatments, but young hamsters aren't good for testing the inhibitory activity of a specific enzyme.
36 citations,
October 2009 in “Journal of biological chemistry/The Journal of biological chemistry” Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.
September 2024 in “International Journal of Molecular Sciences” Hydrangea serrata extract may promote hair growth and improve hair health.
6 citations,
March 2014 in “Herba Polonica” Plant extracts may help treat hormone-related hair loss.
1 citations,
February 2022 in “The Journal of Urology” Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.
January 2023 in “Iranian Journal of Pharmaceutical Research” Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.
6 citations,
January 2016 in “Evidence-based complementary and alternative medicine” Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.
6 citations,
March 2003 in “Archiv Der Pharmazie” Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.
September 2018 in “Journal of Experimental & Biomedical Sciences” DK peptides can reduce hair loss by inhibiting the 5α-reductase enzyme and have antioxidant effects.
3 citations,
August 2021 in “Uro” Saw palmetto may improve urinary symptoms with fewer sexual side effects compared to some medications.
22 citations,
January 2001 in “Chemical & Pharmaceutical Bulletin” Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
April 2022 in “Molecules” Teak leaf extract contains compounds that could help treat hair loss.
12 citations,
April 1995 in “Journal of Medicinal Chemistry” The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
7 citations,
August 2021 in “Journal of the European Academy of Dermatology and Venereology” Early treatment of fibrosing alopecia in a pattern distribution may improve outcomes.
9 citations,
March 1991 in “Endocrinology” Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.
January 2018 in “Przegla̧d dermatologiczny” Hair loss may increase heart disease risk.
61 citations,
January 2018 in “Cosmetics” Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.
January 2018 in “Elsevier eBooks” 5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.
15 citations,
July 2016 in “Urologic Clinics of North America” Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.
97 citations,
April 2016 in “Andrology” Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.
13 citations,
January 2015 in “Steroids” The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.
147 citations,
June 2011 in “New England journal of medicine/The New England journal of medicine” 5α-reductase inhibitors may prevent prostate cancer but could also raise the risk of more severe cancers.
224 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
13 citations,
August 2007 in “Bioorganic & medicinal chemistry letters” A new compound effectively inhibits human 5α-reductase 1.
235 citations,
September 2004 in “The Journal of urology/The journal of urology” Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.
15 citations,
November 2015 in “Pharmacopsychiatry” α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.
49 citations,
October 2017 in “Nutrients” Equisetum debile extract, especially the ethyl acetate type, may be a promising natural ingredient for anti-hair loss products.
February 2024 in “International Journal of Molecular Sciences” Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.
44 citations,
March 2012 in “Fitoterapia” Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.
45 citations,
September 2000 in “Archives of dermatology” The study found that the enzyme linked to acne is present in the same areas of both acne-affected and normal skin.