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Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

research Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

24 citations, April 2013 in “PLOS ONE”

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

The Efficacy and Safety of 17α-Estradiol (Ell-Cranell Alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study

research The Efficacy and Safety of 17α-Estradiol (Ell-Cranell Alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study

21 citations, January 2012 in “Annals of Dermatology”

17α-Estradiol solution safely improves hair density and thickness in female pattern hair loss.

research Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells

16 citations, January 2018 in “International Journal of Trichology”

Minoxidil may help treat hair loss by reducing inflammation-related gene activity in skin cells.

research Inhibition of Steroid 5 Alpha-Reductase with Finasteride: Sleep-Related Erections, Potency, and Libido in Healthy Men

14 citations, June 1995 in “The Journal of Clinical Endocrinology and Metabolism”

research Anti-Androgenic Curcumin Analogues as Steroid 5-Alpha Reductase Inhibitors

12 citations, March 2017 in “Medicinal Chemistry Research”

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

research Finasteride: A 5 Alpha-Reductase Inhibitor

12 citations, January 1993 in “PubMed”

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations, December 2018 in “Assay and Drug Development Technologies”

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

research A Combination of Pyridine-2, 4-Dicarboxylic Acid Diethyl Ester and Resveratrol Stabilizes Hypoxia-Inducible Factor 1-Alpha and Improves Hair Density in Female Volunteers

8 citations, January 2020 in “International Journal of Cosmetic Science”

The combination of specific chemicals improves hair density in women.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

7 citations, February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

6 citations, August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

research Lichenoid Dermatitis from Interferon Alpha-2a in a Patient with Metastatic Renal Cell Carcinoma and Seronegative HCV

4 citations, April 2016 in “Journal of The American Academy of Dermatology”

A patient with advanced kidney cancer and no hepatitis C developed skin inflammation due to a drug called interferon alpha-2a.

Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

3 citations, January 2018 in “Reproduction, Fertility and Development”

Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.

research Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors

2 citations, January 2014 in “Journal of clinical and investigative dermatology”

Some drugs used to treat immune conditions may cause different types of hair loss.

research Bullous Lesions at Polyethylene Glycol Interferon-Alpha-2a Inoculation Site in a Hepatitis C Virus-Infected Subject

2 citations, January 2007 in “Acta Dermato Venereologica”

A patient developed a blister at the injection site after hepatitis C treatment.

research Identification of Potential Cytochrome P450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design

February 2024

Potential new drugs for treating PCOS were identified.

research Structure of Human Type II 5 Alpha-Reductase Gene

76 citations, September 1992 in “Endocrinology”

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

research Alopecia Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy

42 citations, March 2015 in “Anais Brasileiros de Dermatologia”

Anti-TNF therapy can cause hair loss and skin issues.

research Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

23 citations, January 2001 in “Chemical & Pharmaceutical Bulletin”

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

research Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism

17 citations, October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization

4 citations, November 2022 in “Frontiers in endocrinology”

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond

2 citations, December 2008 in “Journal of Chemical Crystallography”

The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.

research Increased Scalp Skin and Serum 5 Alpha-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

2 citations, September 1997 in “Archives of Dermatology”

research Relative Efficacy of Minoxidil and 5-Alpha-Reductase Inhibitors in the Treatment of Male Androgenetic Alopecia: Protocol for a Network Meta-Analysis Study

1 citations, May 2021

Expression and Distribution of the Guanine Nucleotide-Binding Protein Subunit Alpha-S in Mice Skin Tissues and Its Association with White and Black Coat Colors

research Expression and Distribution of the Guanine Nucleotide-Binding Protein Subunit Alpha-S in Mice Skin Tissues and Its Association with White and Black Coat Colors

1 citations, January 2016 in “Asian-Australasian journal of animal sciences”

The protein GnÎ±s is found more in black mice than white mice and may influence their coat color.

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research Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

research The Efficacy and Safety of 17α-Estradiol (Ell-Cranell Alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study

research Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells

research Inhibition of Steroid 5 Alpha-Reductase with Finasteride: Sleep-Related Erections, Potency, and Libido in Healthy Men

research Anti-Androgenic Curcumin Analogues as Steroid 5-Alpha Reductase Inhibitors

research Finasteride: A 5 Alpha-Reductase Inhibitor

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

research A Combination of Pyridine-2, 4-Dicarboxylic Acid Diethyl Ester and Resveratrol Stabilizes Hypoxia-Inducible Factor 1-Alpha and Improves Hair Density in Female Volunteers

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Lichenoid Dermatitis from Interferon Alpha-2a in a Patient with Metastatic Renal Cell Carcinoma and Seronegative HCV

research Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors

research Bullous Lesions at Polyethylene Glycol Interferon-Alpha-2a Inoculation Site in a Hepatitis C Virus-Infected Subject

research Identification of Potential Cytochrome P450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design

research Structure of Human Type II 5 Alpha-Reductase Gene

research Alopecia Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy

research Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

research Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism

research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization

research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond

research Increased Scalp Skin and Serum 5 Alpha-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

research Relative Efficacy of Minoxidil and 5-Alpha-Reductase Inhibitors in the Treatment of Male Androgenetic Alopecia: Protocol for a Network Meta-Analysis Study

research Expression and Distribution of the Guanine Nucleotide-Binding Protein Subunit Alpha-S in Mice Skin Tissues and Its Association with White and Black Coat Colors

research Crystal Structure and Synthesis of 17α-Acetoxy-6,7-Epoxypregn-4-ene-3,20-dione

research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization

research Crystal Structure and Synthesis of 3β-Benzoyloxy-4-pregnen-16α,17α-epoxy-6,20-dione

research Crystal Structure of Steroid 5-Alpha-Reductase 2 in Complex with Finasteride

research After-Rinsing Hair Growth Promotion of Minoxidil-Containing Amino Alpha-Cyclodextrins

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome