38 citations
,
January 2009 in “Journal of Cutaneous Medicine and Surgery” This case report highlights a woman who developed new-onset alopecia areata after starting adalimumab for psoriatic arthritis, challenging the assumed role of TNF-alpha in the condition's pathogenesis.
2 citations
,
January 2014 in “Journal of clinical and investigative dermatology” This article reviews TNF-α inhibitor-induced alopecia, identifying various types of hair loss such as severe alopecia areata and scarring alopecia, and calls for more controlled studies to better understand this adverse effect.
13 citations
,
August 2013 in “Journal of pharmaceutical sciences” This study found that a transdermal delivery system using 3% azone and P407 gel may enhance the skin permeation of doxazosin and finasteride for treating benign prostatic hyperplasia.
109 citations
,
October 2007 in “Journal of pineal research” This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.
92 citations
,
June 2005 in “Journal of Investigative Dermatology” This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.
90 citations
,
October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
78 citations
,
June 2021 in “Dermatology and Therapy” This study highlights the evolving understanding of acne's pathophysiology and suggests that targeting pro-inflammatory cytokines such as IL-1β, IL-17, IL-23, and TNFα with biological antibodies may offer new treatment strategies for severe acne and its scars.
65 citations
,
May 2006 in “Journal of Investigative Dermatology” This study found that dexamethasone significantly reduced ERα mRNA levels and increased aromatase mRNA and activity in cultured human hair follicle dermal papilla cells, suggesting a glucocorticoid-dependent mechanism for estradiol action.
55 citations
,
March 2005 in “Neuropharmacology” A neurosteroid can reduce caffeine-induced anxiety in rats.
48 citations
,
January 2000 in “Hormone Research in Paediatrics” This article reviews the regulation of androgens in human skin and adrenals, highlighting their role in skin disorders, but reports no new research findings.
45 citations
,
August 2009 in “American Journal Of Pathology” Noggin promotes skin tumors by activating certain cell signaling pathways.
38 citations
,
December 2009 in “Therapeutic Advances in Medical Oncology” This discussion proposes a model to incorporate patients with hormone-resistant prostate cancer into the existing framework by redefining hormone resistance and exploring new therapeutic approaches.
24 citations
,
April 2013 in “PLOS ONE” This study identifies substance P, TNFα, and IFNγ as novel regulators of prolactin and its receptor expression in human skin, suggesting intracutaneous prolactin is not controlled by dopamine.
22 citations
,
March 2018 in “American Journal of Clinical Dermatology” New acne treatments show promise as alternatives to traditional therapies.
16 citations
,
April 2017 in “Journal of Cosmetic Dermatology” This study found that fig leaf extract significantly downregulated inflammatory and androgenic gene expression in vitro, suggesting potential topical benefits for certain skin disorders.
October 2025 in “Frontiers in Toxicology” This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.
86 citations
,
April 2016 in “Nature Communications” This study suggests that Notch1 acts as a key signal in skin epithelium, promoting immune cell recruitment and aiding in normal skin repair after damage.
69 citations
,
September 2006 in “Human Reproduction” This study found that CD45RO+ cells, a subtype of T lymphocytes, were notably reduced in the ovarian follicles of women with PCOS, which may contribute to the condition's pathogenesis.
65 citations
,
June 2020 in “Stem Cell Research & Therapy” This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.
65 citations
,
August 2007 in “Experimental Dermatology” This study found that prostaglandin metabolism enzymes are present in human hair follicles, suggesting a potential role in hair growth and differentiation, with some expression differences between men and women.
55 citations
,
January 2002 in “Journal of liposome research” This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.
17 citations
,
September 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that anthralin and mechlorethamine were the most effective therapies among those tested in AA-affected rodent models, providing a basis for further analysis of their mechanisms in Alopecia Areata.
7 citations
,
February 2023 in “Inflammation and Regeneration” This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.
7 citations
,
September 2020 in “Frontiers in Cell and Developmental Biology” This study found that recombinant murine IL-36α increased the number of regenerated hair follicles and accelerated wound healing in a mouse model of wound-induced hair follicle neogenesis.
3 citations
,
March 2014 in “Turkderm” This article reviews the causes, clinical features, and treatment options for androgenetic alopecia, but provides no new clinical findings.
3 citations
,
July 2013 in “Bioscience, Biotechnology, and Biochemistry” This study found that topically applied Chinese black tea extract, when fermented and combined with capsaicin, significantly promoted hair growth in mice, potentially involving estrogen receptor interactions.
1 citations
,
July 2012 in “Nasza Dermatologia Online” This study found that patients with alopecia areata had significantly higher serum levels of IL-1α compared to healthy controls, with no significant difference observed in IL-1β levels.
169 citations
,
May 2006 in “Genes & Development” This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.
48 citations
,
January 2003 In this study, researchers isolated and identified diverse endophytes from plants in Asia, finding that these microorganisms have significant potential for producing useful metabolites, including enzymes and antibiotics.
6 citations
,
July 2013 in “Experimental and Therapeutic Medicine” This study found that topical ginsenoside Rg1 may protect skin from UVB-induced damage in mice by reducing pathological changes and modulating cytokine mRNA expression associated with inflammation and immune response.