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Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

The document suggests creating a secure database for indigenous knowledge and recommends that the TKDL actively fight patents that slightly alter traditional knowledge.

Sebum production varies by individual and is influenced by age, gender, and hormones, affecting skin and hair health.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Birth control pills with low-dose estrogen and antiandrogenic progestins can effectively treat acne.

Cedrus libani has potential medicinal uses but needs more safety studies.

Cancer treatments targeting specific cells often cause skin, hair, and nail problems, affecting patients' lives and requiring careful management.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Single-cell engineered biotherapeutics show promise for skin treatment but need more research and trials.

Mothers have more hair proteins than their children, with age-related differences in protein patterns, and some proteins in hair could indicate early childhood development.

MPZL3 is crucial for seborrheic dermatitis development.

Keratin hydrogels from human hair show promise for tissue engineering and regenerative medicine.

Skin issues can indicate immune system problems.

Yoga and Ayurveda, including stress management and herbal oil use, can potentially reduce hair loss and promote hair growth, with further research needed for therapy protocols.

Dermal stem cells help regenerate hair follicles and heal skin wounds.

Certain skin proteins can form anchoring structures without the protein AMACO.

People with severe hair loss (Alopecia Areata) have different scalp bacteria than healthy people, which might help predict the condition's progress.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

The study found that the hair loss condition in Cesky Fousek dogs is influenced by multiple genes affecting skin and muscle structure, fat metabolism, and immunity.

Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Sex hormones, especially androgens, play a key role in causing acne.

A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.

Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

Resistance exercise can reduce muscle protein issues caused by finasteride.