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Understanding hair follicles through various models can help develop new treatments for hair disorders.

Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Taking 5 alpha reductase inhibitor medication slightly increases the risk of depression, especially as you get older.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

Certain drugs, especially antiandrogens and spironolactone, significantly increase the risk of gynecomastia.

Bimatoprost, a glaucoma medication, may also help treat hair loss.

Fluoxetine's effectiveness as an antidepressant in mice depends on a specific protein activity and a 5-minute pretest.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Melandrium firmum extract helps mice grow hair by blocking a hair loss enzyme and changing hair growth genes.

CLE40 and CRN/CLV2 pathways have opposite effects on root growth in Arabidopsis.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Compounds from certain trees used by First Nations people show potential for treating skin conditions and promoting hair growth, but more research is needed to confirm their safety and effectiveness.

Hormonal therapies help treat female hair loss, but results are slow and vary.

Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.

Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.

Hormonal therapy is effective for treating acne in adult women, especially with signs of high androgen levels.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.

Some plants with flavonoids may help treat hair loss and promote hair growth.

ePUKs could be valuable for regenerative medicine due to their wound healing abilities.

The inhibitor DPP can promote hair growth.

Vitamin D receptor is crucial for skin wound healing.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Adenosine complex helps increase hair thickness and density in hair loss.

Sphinganine can reduce hair loss and improve scalp health.