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Dutasteride is safe and effective for treating hair loss, but may decrease libido.

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

Taking 5-alpha reductase inhibitors does not increase the risk of breast cancer in men.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Rice bran extract might help prevent hair loss.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

β-sitosterol and brassicasterol may help treat hair loss.

Minoxidil, finasteride, and low-level laser light therapy are effective FDA-approved treatments for hair loss.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Certain drugs, especially antiandrogens and spironolactone, significantly increase the risk of gynecomastia.

Using finasteride or dutasteride does not increase the risk of male breast cancer.

The study found that the enzyme linked to acne is present in the same areas of both acne-affected and normal skin.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Scale created to measure hair loss in men and women; MK-386 reduces acne; Niaspan treats dyslipidemia; minoxidil increases heart rate.

Ageratum conyzoides L. extract may effectively and safely treat hair loss.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

TNF-alpha inhibitors can cause various immune-related skin issues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.