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This study found that decreased allopregnanolone levels through inhibition or intrauterine growth restriction in guinea pigs were linked to altered brain development markers, suggesting a role for neurosteroids in fetal brain protection and development.

In this study, finasteride dose-dependently inhibited stress-induced increases in allopregnanolone in rats, while enhancing 20alpha-reduction of progesterone without affecting 3alpha-dihydroprogesterone or 11-deoxycorticosterone levels.

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

In this study, withdrawal from progesterone and treatment with finasteride were associated with increased signs of depression-like behavior in female mice, suggesting decreased allopregnanolone levels may play a role.

This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.

This study found that finasteride dose-dependently blocked the acquisition of ethanol drinking in mice and maintained reduced consumption even after treatment ended.

Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.

This study found that the anticonvulsant effects of progesterone against PTZ-induced seizures in mice require conversion to allopregnanolone, as shown by the reversal of these effects with a 5alpha-reductase inhibitor.

This article discusses the history and terminology of toxic epidermal necrolysis but reports no new clinical results.

5α-reduced progestogens may reduce mood issues and brain damage linked to HIV-1 Tat.

This study found that progesterone can inhibit spinal reflex potentiation in ovariectomized rats through GABA(A) receptor activity, mediated by neurosteroid metabolism rather than direct progesterone receptor action.

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

This study suggests that both the central biosynthesis and metabolism of progesterone to 3α,5α‐THP in the ventral tegmental area are crucial for facilitating lordosis in female rats.

This study found that finasteride increased fetal arousal activity in late gestation sheep by suppressing pregnane steroid synthesis, suggesting reduced GABAA receptor-mediated inhibition.

Early-life neurosteroid changes affect adolescent exploration and adult behavior.

This study indicates that progesterone’s anesthetic activity in PR knockout mice is not due to progesterone receptors but is partially mediated by the neurosteroid allopregnanolone through GABAA receptor potentiation.

This study found that suppressing allopregnanolone production in late gestation fetal sheep altered CNS activity and behavioral responses to transient asphyxia, effects mitigated by an analog co-infusion.

This study found enhanced remyelination in the corpus callosum of late pregnant rats compared to virgin and postpartum rats, suggesting a pregnancy-associated promyelinating effect mediated, in part, by the GABA A receptor system.

This editorial discusses the hormonal basis of catamenial epilepsy, particularly focusing on the roles of progesterone and neurosteroids, and presents no new research findings.

This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.

Olanzapine reduces stress-related anxiety in rats when given acutely.

Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.

This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.

This article discusses the functions of the enzyme 17beta-HSD10, including its role in steroid metabolism and potential links to Alzheimer's disease, but reports no new experimental findings.

In this study using rat hippocampal cultures, progesterone and testosterone showed neuroprotective effects against oxygen-glucose deprivation-induced neuronal cell death, while metabolism of these hormones in the brain may affect their protective actions.

This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.

Neurosteroids in the brain can increase or decrease seizure risk in mice.

This study suggests that neurosteroids, particularly allopregnanolone, may play a crucial role in the progression and management of epilepsy, as indicated by their effects on seizure modulation in both rats and humans.

Finasteride slows down motherly behavior in first-time pregnant rats.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.