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In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.

In this study, high-dose dutasteride significantly reduced several core symptoms of PMDD compared to placebo, supporting the role of neurosteroids in this condition.

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

This study found that in rats, finasteride significantly reduced allopregnanolone in the cortex and increased both the rise and duration of dopamine levels in the prefrontal cortex in response to stress and anxiogenic stimuli.

This study found that progesterone reduces neuronal injury from tributyltin exposure in rat hippocampal slices through a mechanism dependent on allopregnanolone and GABAA receptors.

This study suggests that in late pregnancy, allopregnanolone induces opioid inhibition of oxytocin secretion in response to immune challenge, potentially minimizing the risk of preterm labor in rats.

Female mice are less affected by certain substances that alter alcohol consumption compared to male mice.

This study found that augmenting or reducing allopregnanolone activity in the BNST affected contextual fear expression in rats, suggesting sex differences in anxiety may be linked to neuroactive steroid regulation.

This study found that progesterone can increase glycine release in rat brainstem neurons through its conversion to allopregnanolone, which modulates presynaptic GABA receptor activity.

This study suggests that stress may worsen Tourette syndrome symptoms in mice by increasing allopregnanolone synthesis, with findings supporting finasteride as a potential treatment to manage symptom fluctuations.

This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.

This study found that altering Allopregnanolone levels in neonatal rats affects their adult exploratory and anxiety-like behaviors and impairs avoidance learning.

This study suggests that the neurosteroid allopregnanolone contributes to stress resistance in mice, and the ALLO mimetic drug alfaxalone may offer anxiolytic benefits without muscle-relaxant effects.

Neonatal neurosteroid levels affect adult brain function and behavior.

This study found that in newborn rats, progesterone's effects on apnoea frequency are influenced by a sex-specific balance between its metabolite allopregnanolone and progesterone receptors.

This study found that in newborn rats treated with caffeine, progesterone increased apnoea frequency by inhibiting breathing, suggesting it may not be suitable for preterm neonates without addressing allopregnanolone's effects.

This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.

Allopregnanolone likely doesn't influence ethanol's rewarding effects in these mice.

This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.

In this study, paroxetine's antihyperalgesic effect in a rat model of neuropathic pain was shown to be mediated by increased levels of the neurosteroid allopregnanolone in the spine.

This study found that altering neurosteroid levels during early development in male rats can influence KCC2 levels, underscoring the role of neurosteroids in hippocampal maturation.

This study suggests that the progesterone metabolite allopregnanolone and progesterone regulate distinct gene sets involved in glioblastoma cell proliferation, with some overlapping effects modified by finasteride.

This study found that pre-treatment with the neurosteroid allopregnanolone in mice reduced nicotine withdrawal symptoms, suggesting potential therapeutic benefits for nicotine dependence.

This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.

This study found that low-intensity exercise improved pain relief in aged rats through increased brain allopregnanolone levels, while high-intensity exercise was effective in both adult and aged rats via a different mechanism.

In this study, finasteride-treated WAG/Rij rats showed a significant increase in spike-wave discharges when administered endogenous steroids THPROG and THDOC, indicating potential exacerbation of absence seizures.

This review discusses the potential link between early postnatal allopregnanolone levels and vulnerability to drug abuse in adulthood, noting a need for more in-depth studies to confirm this relationship.

This study hypothesized that finasteride administration may increase stress-induced amphetamine locomotor sensitization due to its impact on brain reward systems involving the neurosteroid allopregnanolone.