research Combined AlloDerm® and thin skin grafting for the treatment of postburn dyspigmented scar contracture of the upper extremity
Technique effectively treats deformities, achieves re-pigmentation, and releases scar contractures.
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research Wound Healing: A Cellular Perspective
This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
research Regenerative Medicine of Epidermal Structures
This chapter reviews therapies for skin and corneal regeneration and hair loss, discussing various treatments but presenting no new research findings.
research Neovascularization during healing of wounds treated with dermal substitutes and fibrin glue in nude mice
Dermagraft and Dermalogen had a lot of granulation, while Alloderm, Integra, and ADM had good blood vessel growth for skin healing.
research Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration
This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.
research Efficient scarless skin regeneration enabled by loading micronized amnion in a bioinspired adhesive wound dressing
In this study, a hydrogel derived from Andrias davidianus secretion, combined with micronized amnion, promoted skin regeneration and achieved scarless healing in rats, suggesting potential for clinical use.
research Lateral plate mesoderm directs human amnion and ventral skin organoid formation
In this study, researchers engineered ventral skin organoids (vSkOs) with specific cellular compositions and signaling environments to generate human amnion-like tissues called Amnioids, offering new tools for studying human development and potential regenerative therapies.
research Design of an artificial skin. IV. Use of island graft to isolate organ regeneration from scar synthesis and other processes leading to skin wound closure
This study found that island grafting in guinea pigs enabled the isolated study of early skin regeneration processes, distinguishing them from natural wound closure mechanisms like epithelialization and contraction.
research Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration
In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.
research Althaea officinalis improves wound healing in rats: a stereological study
This study observed that Althaea officinalis gel increased fibroblast populations, hair follicles, and vessel diameter in rat wounds, suggesting it might aid wound healing, though further clinical studies are needed.
research Axolotl-derived decellularized skin ECM as a pro-regenerative scaffold for attenuating fibrotic wound healing
In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.
research Preparation and experiment study on a new type artificial derma
This study found that a new-type artificial xenogenic derma exhibited better biocompatibility and dermal tissue regeneration ability compared to cross-linked acellular dermal matrix in a mouse model.
research A Multimodal Approach to Augmenting Wound Healing: Progress Toward Dermal Regeneration in Mammals
This research reported that dermal progenitor cells can enhance split-thickness skin graft outcomes by improving dermal layer qualities and reducing itch and offer potential in skin wound healing using a flowable hydrogel for better cell delivery and survival.
research Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein
This study found that encapsulating dermal papilla spheroids in alginate hydrogel with extracellular matrix proteins increased alkaline phosphatase activity, suggesting an enhanced manipulation of dermal papilla activity.
research Immunoguided cutaneous regeneration: a theoretical framework linking extracellular matrix, immunity, and skin allografts
This study introduces Immunoguided Cutaneous Regeneration as a potential framework for understanding skin allotransplantation, suggesting that regeneration may depend on the preserved extracellular matrix and a regulated immune response.
research Alginate and its application to tissue engineering
This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.
research 779 Multicellular skin organoids as a unique modeling platform for skin physiology, injury, and disease
The new skin organoid system effectively mimics human skin for studying its functions, injuries, and diseases.
research LB1774 Establishing competent morphogenetic fields for tissue pattern regeneration in skin organoids
Skin organoids can regenerate hair by forming specific cell units with certain signals.
research The repairing of full-thickness skin deficiency and its biological mechanism using decellularized human amniotic membrane as the wound dressing
In this study, decellularized human amniotic membrane was found to promote wound healing and reduce scar formation in rats with full-thickness skin defects, compared to traditional clinical treatments.
research ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1
This study found that acellular dermal matrix scaffolds may facilitate full-thickness skin wound healing by promoting a pro-regenerative immune response through M2 macrophage polarization via the Lamtor1 pathway.
research FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE
This study suggests that human outer root sheath cells are suitable for skin replacement, as they can form a stratified epithelium similar to normal epidermis in organotypic cultures.
research Restructuring skin equivalents with human hair follicle orscs and fibroblasts
A new method was developed to create better skin models for healing and reconstruction.
research In-vitro and In-vivo Characterization of Bio-Patch to Hydrogel on Skin Wounds for Efficient Scarless Wound Healing
In this study, a multifunctional aloin-arginine-alginate bio-patch was developed, which transforms into a hydrogel to accelerate wound healing and offers antibacterial and anti-inflammatory benefits, making it promising for use in cutaneous regeneration.
research Herstellung eines Hautäquivalentes mit Hilfe von humanen Zellen der Haarwurzelscheide und Fibroblasten
This study reported that a skin equivalent model using human outer root sheath cells and fibroblasts showed the formation of structures similar to human dermis and epidermis within two weeks after transplantation into mice.
research Monoolein-alginate beads as a platform to promote adenosine cutaneous localization and wound healing
This study found that alginate beads containing monoolein demonstrated promising potential for managing wet wounds by better absorbing excess exudate and delivering adenosine locally, favoring drug localization in damaged porcine skin compared to an aqueous solution without affecting skin viability.
research Epidermis reconstructed from the outer root sheath of human hair follicle on de-epidermized dermis. Effect of retinoic acid
research Skin Epidermis and Adnexa Regrowth Induced by Treatment With Artificial Dermal Template After Full-Thickness Skin Wound
This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.
research Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid
Human hair follicles can be used to create skin-like tissue for wound healing and drug testing.
research Scaffolds for epidermal tissue engineering
This review discusses scaffold materials and properties used in epidermal tissue engineering to promote skin regeneration and reports no new research findings.
research Skin organoids: A new human model for developmental and translational research
This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.