This study introduced a customizable ELISA for detecting antibodies against botulinum neurotoxin that matches or surpasses other tests in sensitivity and allows for more efficient and animal-friendly testing when combined with the hemidiaphragm assay.
September 2004 in “Experimental Dermatology” This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.
215 citations
,
November 2000 in “Journal of Investigative Dermatology” This study found that the tetracycline-regulated transcription system effectively controls conditional gene expression in the mouse epidermis, allowing suppression and activation of specific genes with doxycycline.
135 citations
,
October 1997 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that trichohyalin is modified by peptidyl-arginine deiminase before being cross-linked by TGase 3, allowing the formation of rigid structures in hair follicle cells.
83 citations
,
February 1977 in “PubMed” This study found that exposing seasonally anestrous mares to extended light periods led to the earlier onset of endocrinologically normal estrous cycles, potentially allowing earlier breeding and foaling.
53 citations
,
June 1983 in “Journal of Investigative Dermatology” This study reports that human epidermal transglutaminase activity increases with treatment using organic solvents and chemicals without significant molecular weight changes, which may allow modulation of the enzyme in skin diseases.
39 citations
,
January 2012 in “Acta dermato-venereologica” This study examined 27 DRESS patients diagnosed in Thailand, identifying phenytoin, allopurinol, and nevirapine as common causes, with a 3.7% mortality rate and systemic corticosteroids being a common treatment.
37 citations
,
August 2019 in “Frontiers in Microbiology” This study found that the S. epidermidis A/C lineage is more pathogenic due to its metabolic and genomic versatility, which allows it to adapt quickly from a commensal to a pathogenic lifestyle.
35 citations
,
July 2009 in “Optics express” This study introduces a new intracavity frequency modulation technique for tunable picosecond optical parametric oscillators, enhancing chemical contrast in coherent Raman imaging by allowing real-time subtraction of background signals.
33 citations
,
July 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the use of nanocarrier technology in functional cosmetics to enhance skin penetration, increase ingredient stability, and allow codelivery of active ingredients, without reporting new clinical results.
33 citations
,
November 2019 in “Journal of Controlled Release” In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.
28 citations
,
October 1978 in “Archives of dermatology” This study found that combined topical, intralesional, and oral corticosteroids led to significant hair regrowth in some patients with alopecia totalis or universalis, allowing eventual cessation of oral corticosteroids in several cases.
25 citations
,
June 2017 in “Neuropharmacology” This study observed that overexpressing TSPO in the hippocampal dentate gyrus of mice led to significant anxiolytic and antidepressant-like effects, potentially mediated by increased allopregnanolone synthesis.
22 citations
,
October 2000 in “British Journal of Haematology” This article discusses the development of non-myeloablative stem cell transplants, which may expand the safe treatment range of allogeneic SCT, but presents no new clinical results.
20 citations
,
August 2005 in “The Journal of laboratory and clinical medicine” In this study, researchers observed that epidermal damage may increase susceptibility to Bacillus anthracis infection, allowing it access through hair follicles and the denuded dermis in mice.
15 citations
,
January 2019 in “Experimental Dermatology” In this study, full-thickness wounding on Lanyu pigs led to scar formation and disrupted cell markers, while partial-thickness wounding allowed limited regeneration of rete ridges and papillary dermis.
14 citations
,
November 2016 in “Lupus” In this retrospective study of adolescents with recalcitrant cutaneous lupus, lenalidomide treatment resulted in complete or near resolution of skin symptoms within 6 months, while allowing for a reduction in prednisone dosage.
14 citations
,
February 2014 in “Nutrition in Clinical Practice” This A.S.P.E.N. document offers guidance for managing parenteral nutrition shortages, emphasizing alternative routes and careful allocation to prevent deficiencies.
13 citations
,
January 2019 in “Skin appendage disorders” This study reported that fibrosing alopecia in a pattern distribution can occur in patients of color, with clinical and histopathological features allowing for an accurate differential diagnosis.
11 citations
,
May 2010 in “Journal of the South African Veterinary Association” This case report describes how a treatment with mycophenolate mofetil and prednisone may be effective in managing autoimmune subepidermal blistering dermatosis in dogs while allowing for steroid reduction.
11 citations
,
January 1987 in “Electrophoresis” This study found that keratin phenotypes were consistent across different types of hair from the same individual, allowing for successful keratin typing following ABH blood group determination.
10 citations
,
August 2023 in “The EMBO Journal” This study explored the epigenetic mechanisms of dermal fibroblast progenitor differentiation and found that the repressive chromatin profile from H3K27me3 prevents these progenitors from reforming skin in allograft assays, despite their multipotent potential.
9 citations
,
October 2022 in “Nature Communications” In this study, researchers developed a new photoactivatable Cre recombinase mouse model, DiLiCre, which allows precise light-induced genetic modifications and cell tracing, demonstrating its effectiveness for advancing biological and biomedical research.
8 citations
,
January 2005 in “Acta Oto-Laryngologica” This case study reports that ciclosporin effectively managed symptoms in a patient with steroid-dependent sudden sensorineural hearing loss, allowing discontinuation of corticosteroids and confirming remission through audiometry.
8 citations
,
July 1984 in “The Journal of Dermatologic Surgery and Oncology” This study found that using a specific donor row configuration with suturing improves both short-term and long-term scarring, allowing 10-15% more grafts to be taken while maintaining finer donor scars.
7 citations
,
May 2017 in “Research and Practice in Thrombosis and Haemostasis” This case report observed that a 20-year-old female with recurrent DVTs experienced reversible alopecia with various anticoagulants, except fondaparinux which allowed long-term treatment without this side effect.
6 citations
,
August 2021 in “International Journal of Pharmaceutics” This study demonstrated that finasteride-loaded PLGA microspheres created using a novel microfluidic device exhibit extended drug release in beagle dogs, with modifications allowing for release up to 3 months.
6 citations
,
January 2014 in “Genetics and Molecular Research” This study constructed a hair follicle-specific expression vector for IGFBP-5 in Inner Mongolia Cashmere goat cells, allowing for future functional genetic analyses and potential use in nuclear transfer.
5 citations
,
February 2024 in “Frontiers in bioengineering and biotechnology” This research review outlines the challenges of diabetic wounds, such as diabetic foot ulcers, and examines the potential of electrospinning nanofiber scaffolds to improve healing by promoting tissue formation, allowing drug release, and enhancing specific wound healing properties.
5 citations
,
March 2019 in “Scientific Reports” This study reports that the side population technique can isolate melanocyte stem cells from human hair follicles, potentially allowing them to be used for skin pigmentation repopulation.