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Humans lost body hair relatively recently in evolution.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Cathepsin L is essential for normal hair growth and development.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Fat cells in the skin help start healing and form important repair cells after injury.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.