10 citations
,
May 2017 in “Wound Repair and Regeneration” In this study, targeted overexpression of the BMP receptor ALK2 in mouse hair follicle stem cells altered follicle structure and impaired cutaneous wound healing.
29 citations
,
January 2020 in “Frontiers in endocrinology” This paper considers fibrodysplasia ossificans progressiva as a segmental progeroid syndrome, which may help uncover mechanisms of normal aging and suggest targets for new treatments.
245 citations
,
January 2018 in “Bone Research” This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.
156 citations
,
December 2012 in “Cell Stem Cell” This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
62 citations
,
August 2018 in “Frontiers in Endocrinology” This review discusses the physiological roles of ovarian androgens in follicle development and atresia, emphasizing their contributions to polycystic ovary syndrome and normal follicle maturation but provides no new clinical results.
29 citations
,
December 2012 in “Fibrogenesis & Tissue Repair” This review discusses the roles of tissue-specific and mesenchymal stromal cells in tissue repair and reparative disorders, highlighting potential therapeutic targets for muscle, heart, and lung tissues.
11 citations
,
December 2018 in “Bone” This study found that a high-energy shock wave can increase osteogenic activities in human mesenchymal cells, offering insights into potential therapeutic targets for trauma-induced heterotopic ossification.
5 citations
,
January 2005 in “Cytotherapy” This meeting in Heidelberg highlighted diverse contributions on stem cell research, including pre-clinical and clinical applications, but reported no new experimental results.
4 citations
,
November 2023 in “Frontiers in immunology” In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.
1 citations
,
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study explores ear pinna development in mice and reports that elastic cartilage formation is disrupted in a short ear mutant, correlating with increased adult adipocytes and impaired chondrogenesis.
176 citations
,
January 2003 in “Journal of Investigative Dermatology” This review summarizes the roles of bone morphogenetic proteins in the development and regulation of normal and diseased skin, but it does not provide new clinical results.
132 citations
,
August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.
59 citations
,
March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This review examines the roles of Smad-4 and Smad-7 in hair follicle differentiation and development through BMP signaling and TGFβ/Activin/BMP pathway inhibition but reports no new experimental results.
1 citations
,
November 2018 in “Therapeutic Delivery” This industry update reports on various advancements in therapeutic delivery during July 2018, highlighting active mergers, collaborations, and potential developments across fields like gene therapy, immuno-oncology, and rare diseases treatment; however, no new clinical results are presented.
January 2016 in “Research Explorer (The University of Manchester)” Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.
January 2024 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that Carbon Quantum Dots effectively detected and quantified Co²⁺ ions and methylcobalamin in tap water with high sensitivity and recovery rates between 95% and 105%.
32 citations
,
April 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrates that keratin K2 is crucial for proper keratinocyte structure and function in specific mouse skin areas, and its deficiency leads to cellular aggregates and skin abnormalities.
research News
February 2023 in “Chemistry & Industry” 2 citations
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October 2025 in “Cells” This review discusses the multifunctional role of PKM2 in promoting cardiac repair and regeneration, highlighting its potential as a therapeutic target in cardiovascular medicine, but reports no new experimental results.
9 citations
,
January 2018 in “Acta dermato-venereologica” This study found that carbonic anhydrase II was significantly upregulated in human keratinocytes when treated with toll-like receptor 3 agonist and Th2 cytokines, suggesting its potential role in inflammatory skin conditions.
52 citations
,
April 2012 in “Journal of Investigative Dermatology” This study found that KRTAP2 proteins predominantly express in the hair shaft cortex of humans, interact with hair keratins, and play crucial roles in hair shaft keratinization.
119 citations
,
October 1992 in “Fundamental & Clinical Pharmacology” This review discusses the pharmacological properties and therapeutic potential of K+ channel opening compounds, noting their prospective use in treating cardiovascular and respiratory conditions, but reports no new results.
10 citations
,
July 2023 in “Pharmaceutics” In this study using mice and human keratinocyte cells, researchers found that activating PKM2-mediated glycolysis and Wnt/β-catenin signaling, particularly via combined treatments, significantly accelerated wound healing and induced angiogenesis in wound beds.
This study reported that the Fe@C/CB electrocatalyst effectively detected Metol in water samples with a low detection limit, high sensitivity, and good stability, suggesting it as a promising tool for environmental monitoring.
January 2024 in “Research Square (Research Square)” This study reports that adjusting the valence states of Mo in Pluronic F127-coated MoO3-x nanozymes enhances their selective H2O2-related catalytic activity, showing promise in acute kidney injury treatment and enabling real-time monitoring of therapy effectiveness through ROS-responsive photoacoustic imaging.
3 citations
,
January 2006 This chapter discusses various topics in physical organic chemistry, including process research and specific chemical reactions, but it does not report any new research findings.
March 2025 in “International Journal For Multidisciplinary Research” This article reviews innovative methodologies in drug discovery using computational QSAR studies and layered double hydroxides for alpha-reductase inhibitors, but reports no new experimental results.
September 2026 in “Angewandte Chemie International Edition” In this study, SEU-302, a newly synthesized covalent organic framework, demonstrated potent photodynamic antibacterial effects, showing effective elimination of Staphylococcus aureus, wound healing promotion, and inflammation reduction both in vitro and in vivo, highlighting its therapeutic promise against bacterial infections.
180 citations
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February 2023 in “Journal of Chemical Information and Modeling” In this paper, Chemistry42—a software integrating AI with computational and medicinal chemistry—demonstrated efficiency in designing novel molecular structures targeting DDR1 and CDK20, with properties validated in both in vitro and in vivo studies.