December 2012 in “SWU eJournals System (Srinakharinwirot University)” This review discusses temporary chemical hair removal methods involving thioglycolates and other compounds but reports no new clinical findings; the authors highlight interest in natural-based substances.
2 citations
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June 2018 in “Cosmetics” This study found that using an aqueous solution of AMPD in hair bleach reduced both hair damage and odor compared to ammonium hydroxide.
3 citations
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May 2007 in “Journal of Heterocyclic Chemistry” This study reports a new industrial process for making finasteride using novel protective groups, demonstrated through spectral data of newly prepared compounds.
December 2021 in “Benha Journal of Applied Sciences” This study found that high serum alarin levels were linked to both androgenetic alopecia and metabolic syndrome, increasing with the severity of AGA.
August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.
12 citations
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April 2023 in “Pharmaceutics” This review covers the current and potential medical uses of semifluorinated alkanes, including applications in eye surgery, drug delivery, and oxygen transport.
13 citations
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October 2002 in “Journal of Biochemical and Biophysical Methods” This study found that men with androgenic alopecia had significantly higher levels of certain urinary steroid metabolites, suggesting increased 5 alpha-reductase activity and possible mild hyperadrenal activity.
May 2022 in “Current Enzyme Inhibition” This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.
3 citations
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January 2009 in “Sen'i Gakkaishi” This study found that using a bicomponent reduction system with TGA and DTDG for hair straightening limited hair damage by forming only thiol groups, while a TGA-only system formed more damaging mixed disulfide groups.
April 2023 in “Journal of Investigative Dermatology” This study suggests that linalool, a common allergen in personal care products, may contribute to frontal fibrosing alopecia pathogenesis by triggering immune responses and depleting hair follicle stem cells, especially in sensitized individuals.
February 2010 in “Journal of The American Academy of Dermatology” This review examines microbial production and applications of gluconic acid, focusing on the enzymatic processes involved, and offers no new experimental results.
January 2023 in “International Journal of Trichology” This review discusses the positioning of low alcohol or alcohol-free topical minoxidil for managing androgenetic alopecia in Indian clinical practice and reports no new clinical results.
January 2004 in “Side effects of drugs annual” Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.
4 citations
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June 2020 in “Processes” This study suggests that G. sibiricum has potent aldose reductase inhibitory activity, primarily due to kaempferol rhamnosides, and may be further explored as a natural treatment for diabetes-related complications.
6 citations
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February 2019 in “Scientific reports” This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.
December 2025 in “International Journal of Research in Dermatology” In this survey, dermatologists in India reported preferring alcohol-free minoxidil combined with procapil and finasteride over traditional alcohol-based formulations for managing androgenetic alopecia, citing better tolerance and patient adherence.
4 citations
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March 2007 in “Annales de Dermatologie et de Vénéréologie” This review discusses the adverse effects of hair care products, highlighting irritation dermatitis and allergic contact eczema due to common allergens like paraphenylenediamine and glycerol monothioglycolate, but reports no clinical results.
8 citations
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January 2011 in “Organic and Biomolecular Chemistry” Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.
January 2006 in “Benzina: Revista d'excepcions culturals” This study observed that new trienone compounds consistently showed higher 5alpha-reductase inhibitory activity compared to corresponding dienones across various biological models.
March 2026 in “Tropical Journal of Natural Product Research” In this study, the bark extract of Albizia saponaria was analyzed for its metabolites and potential anti-alopecia effects, identifying several compounds with predicted affinities for proteins involved in hair loss pathways.
November 2003 in “Journal of Neurochemistry” This study suggests that the neurosteroid allopregnanolone may play a crucial role in how ethanol affects neurons related to alcohol addiction vulnerability.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.
April 2023 in “Journal of Investigative Dermatology” This study found that overexpression of the lncRNA AL136131.3 may inhibit hair shaft growth and promote hair follicle apoptosis in androgenetic alopecia by influencing key metabolic pathways.
2 citations
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January 1975 in “Archives of Dermatological Research” Certain enzymes react strongly with some hormones in rat skin during hair growth, mainly in sebaceous glands and hair sheaths.
2 citations
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September 1992 in “Steroids” The researchers reported that compounds 11 to 13 derived from Westphalen-type steroids showed strong antiandrogenic activity in vivo, though their effects could not be attributed to 5α-reductase inhibition or androgen receptor binding.
3 citations
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January 2004 in “Sen i Gakkaishi” This study found that adding dithiodiglycolic acid to the hair straightening process decreased chemical damage and preserved the structural integrity of the hair matrix compared to using thioglycolic acid alone.
January 2026 in “International Journal of Biological Macromolecules” This study used a new multimolecular spectral method to uncover structural differences in hair keratin from individuals with androgenetic alopecia compared to healthy individuals, identifying potential biomarkers and providing insights for developing new treatments.
November 2024 in “Dermatitis” This review identifies specific personal care products and allergens commonly causing allergic contact dermatitis in men, which may improve diagnosis and treatment.
11 citations
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March 2009 in “Bioorganic & Medicinal Chemistry Letters” This study reports that 4-(alkylthio)- and 4-(arylthio)-benzonitriles showed moderate sebum reduction as androgen receptor antagonists when applied topically in a validated animal model.
September 2002 in “Research Repository (Kingston University London)” This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.