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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Different human traits like skin color and hair type vary between populations due to genetic adaptations to the environment.

Cirsium japonicum var. spinossimum seeds may help reduce inflammation and fight cancer.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Acitretin treats severe skin conditions but requires careful monitoring due to serious side effects.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Alcohol in teen years leads to more adult drinking, finasteride doesn't help.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

Early NAS level changes affect alcohol consumption vulnerability.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

Different enzymes are active in different parts of developing mouse organs.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

Premature hair graying in young Turkish adults is more likely if they have stress, a family history of graying, drink alcohol, have chronic diseases, are older, or are taller.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

A woman's liver was damaged by taking the herbal supplement Shou-Wu-Pian, but it got better after she stopped using it.

Finasteride overdose can cause acute pancreatitis.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.