research A Variable Monilethrix Phenotype Associated With a Novel Mutation, Glu402Lys, in the Helix Termination Motif of the Type II Hair Keratin hHb1
A new mutation, Glu402Lys, in hair keratin is linked to variable symptoms of monilethrix.
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90-120 / 1000+ resultsresearch Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.
This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.
research Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis
This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.
research Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series
In this study, the combination of pulse intravenous corticosteroids and methotrexate was associated with positive hair regrowth in severe alopecia areata patients, with half achieving total regrowth.
research Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments
This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.
research Beyond vitiligo guidelines: combined stratified/personalized approaches for the vitiligo patient
This article discusses the need for a personalized and stratified therapeutic approach for vitiligo, utilizing current knowledge and expertise, but it does not report new clinical results.
research Outer root sheath (ORS) cells organize into epidermoid cyst-like spheroids when cultured inside Matrigel: a light-microscopic and immunohistological comparison between human ORS cells and interfollicular keratinocytes
research Unusual Microsporum canis infections in adult HIV patients
This study reports two HIV-infected men with a rare M. canis infection unresponsive to ketoconazole and terbinafine, where itraconazole was effective but prolonged treatment led to only one cure.
research Organotypic culture of outer root sheath cells from human hair follicles using a new culture device
The new device improves human hair follicle cell growth and differentiation.
research Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
This study found that active androgens activate lipogenic differentiation in human sebocytes expressing a functional androgen receptor, influencing gene expression and lipid synthesis, while also increasing apoptotic cell population over time.
research Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells
This study found that distinct keratin profiles enabled the evaluation of epithelial differentiation in human hair follicles, with mesenchymal cells playing a critical role in epidermoid differentiation of follicular cells.
research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?
This study suggests that TGase 3 may contribute to hair fiber scaffolding by forming specific isopeptide bonds between keratin intermediate filaments and keratin-associated proteins.
research Signalling by senescent melanocytes hyperactivates hair growth
In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.
research Skin manifestations amongGATA2-deficient patients
Patients with GATA2 deficiency show early skin symptoms that help diagnose the condition.
research Autofluorescence as a Signal to Sort Developing Glandular Trichomes by Flow Cytometry
This study describes a method to isolate and analyze young and mature type VI trichomes from wild tomato species using autofluorescence-based cell sorting.
research B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance
In this study, knockout of B-raf and C-raf genes in mice showed they are not needed for early melanocyte development, but are crucial for maintaining melanocyte stem cells, as evidenced by hair graying due to stem cell depletion.
research Safe Selection of Genetically Manipulated Human Primary Keratinocytes with Very High Growth Potential Using CD24
This study found that using ectopic expression of CD24 is a promising approach for selecting genetically modified human epidermal stem cells for safe cutaneous gene therapy in cancer-prone conditions.
research Lymphocytic Infiltration of the Skin Jessner-Kanof After Treatment With a Hydroquinone-Containing Bleaching Cream
research Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options
This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.
research The Expression of Vitamin D-Upregulated Protein 1 in Skin and its Interaction with Sciellin in Cultured Keratinocytes
This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.
research Organotypic Cocultures as Models to Study Cell-Cell and Cell-Matrix Interactions of Human Hair Follicle Cells
This study observed that in vitro cocultures of hair follicle cells with dermal fibroblasts or hair papilla cells enhanced proliferation and differentiation of outer root sheath cells but did not mimic hair-type differentiation.
research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System
The study reports that the AVET system showed higher efficiency in transfecting cultured human keratinocytes compared to SuperFect and PrimeFector, with AVET reaching levels of enzyme activity similar to normal cells in keratinocytes from lamellar ichthyosis patients.
research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature
This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.
research High‐dose pulsed corticosteroid therapy combined with methotrexate for severe alopecia areata of childhood
This article is a letter to the editor about high-dose pulsed corticosteroid therapy combined with methotrexate for severe childhood alopecia areata and provides no new clinical results.
research Hair Casts
This study reports that 0.025% tretinoin lotion seemed effective for idiopathic hair casts in two young girls and suggests an infrainfundibular origin for the lesions.
research Clinical repigmentation patterns in paediatric vitiligo
This study found that a combined pattern of repigmentation was most commonly observed in vitiligo, with a new 'medium spotted' pattern proposed for areas with few hair follicles.
research FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE
This study suggests that human outer root sheath cells are suitable for skin replacement, as they can form a stratified epithelium similar to normal epidermis in organotypic cultures.
research Testosterone Prevents Cutaneous Ischemia and Necrosis in Males Through Complementary Estrogenic and Androgenic Actions
This study in male mice found that testosterone provides strong protection against skin necrosis after ischemia, working through its estrogenic and androgenic derivatives to enhance skin survival and revascularization, with 17β-estradiol being notably more effective than dihydrotestosterone.
research Effect of dietary supplementation with INVERSION® femme on slimming, hair loss, and skin and nail parameters in women
This study found that the oral supplement INVERSION® Femme significantly reduced weight and hair loss and improved skin and nails in overweight women.
research Phenotypic modulation of human hair matrix cells (trichocytes) by environmental influence in vitro and in vivo.
In this study, trichocytes were shown to have potential for alternative differentiation, with mesenchymal cell influences playing a critical role in determining this process.