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      A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

      research A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

      113 citations , April 1999 in “The Journal of Clinical Endocrinology and Metabolism”
      This study found that all four treatments—flutamide, finasteride, ketoconazole, and EE-CPA—significantly reduced hirsutism, but EE-CPA and flutamide appeared most effective, with varying effects on androgen levels and side-effect profiles.
      Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      research Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      112 citations , November 2023 in “Nano-Micro Letters”
      This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
      Targeting the Wnt Pathways for Therapies

      research Targeting the Wnt pathways for therapies

      112 citations , January 2014 in “Molecular and cellular therapies”
      This review summarizes the current understanding of Wnt signaling in relation to its roles in tissue regeneration and cancer progression and discusses recent medical advancements targeting this pathway for therapeutic purposes.
      Fullerene Nanoparticles in Dermatological and Cosmetic Applications

      research Fullerene nanoparticle in dermatological and cosmetic applications

      101 citations , October 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine”
      This review reports on the dual aspect of fullerene in skincare, highlighting its beneficial antioxidant properties as well as potential toxicity and skin cell reactions, while identifying areas for future research.
      Adverse Effects of Voriconazole: Over a Decade of Use

      research Adverse effects of voriconazole: Over a decade of use

      100 citations , September 2016 in “Clinical transplantation/Clinical transplantation.”
      This study highlights that prolonged voriconazole use is linked to an increased risk of aggressive cutaneous malignancies like squamous cell carcinoma, necessitating careful monitoring of drug levels to manage adverse effects.
      Pharmacology of Antiandrogens

      research Pharmacology of antiandrogens

      97 citations , November 1986 in “Journal of Steroid Biochemistry”
      This review discusses the pharmacological properties and clinical applications of cyproterone acetate and similar antiandrogens, noting previous failures in local applications due to concentration limitations; it reports no new empirical results.
      Primary Cicatricial Alopecia: Treatment Approaches and Classification

      research Primary cicatricial alopecia

      95 citations , November 2016 in “Journal of The American Academy of Dermatology”
      This article reviews primary cicatricial alopecias, focusing on lymphocytic forms such as chronic cutaneous lupus erythematosus, according to a classification by the North American Hair Research Society, and reports no new clinical results.
      Polycystic Ovary Syndrome: Update on Diagnosis and Treatment

      research Polycystic Ovary Syndrome: Update on Diagnosis and Treatment

      92 citations , May 2014 in “The American Journal of Medicine”
      This review discusses the multi-system impacts of polycystic ovary syndrome and explores evaluation and treatment strategies, but it reports no new research findings.
      Polycystic Ovarian Syndrome: Comprehensive Overview and Management Approaches

      research Polycystic Ovarian Syndrome

      89 citations , November 2014 in “Medical Clinics of North America”
      This article reviews management strategies for PCOS and reports no new clinical results; the authors highlight oral contraceptives, lifestyle modifications, and metformin as key interventions.
      Physiological Functions of PP2A: Lessons from Genetically Modified Mice

      research Physiologic functions of PP2A: Lessons from genetically modified mice

      87 citations , July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”
      This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.
      No Evidence for the Immunocompetence Handicap Hypothesis in Male Humans

      research No evidence for the immunocompetence handicap hypothesis in male humans

      87 citations , May 2018 in “Scientific Reports”
      This study found that in healthy men, higher levels of free testosterone were associated with a stronger immune response to the influenza vaccine, suggesting androgens may function as immunomodulators rather than strict immunosuppressants.
      Adult Kawasaki Disease: Report of Two Cases and Literature Review

      research Adult Kawasaki Disease: Report of Two Cases and Literature Review

      86 citations , May 2005 in “Seminars in Arthritis and Rheumatism”
      This review identified distinguishing features of adult Kawasaki Disease compared to pediatric cases, noting more favorable prognosis in adults with fewer cardiovascular complications and no fatalities, although it remains a rare and often unrecognized condition.
      Nanozymes Expanding the Boundaries of Biocatalysis

      research Nanozymes expanding the boundaries of biocatalysis

      85 citations , July 2025 in “Nature Communications”
      This review examines the evolving field of nanozymes, highlighting their unique properties and biocatalytic capabilities that challenge traditional concepts of biocatalysis, with implications for sustainable applications and potential roles in physiological processes and disease pathogenesis.
      Severe Acute Respiratory Syndrome (SARS)

      research Severe Acute Respiratory Syndrome (SARS)

      84 citations , March 2010 in “Infectious Disease Clinics of North America”
      The document concludes that rapid identification, isolation, and strict infection control are crucial to manage SARS outbreaks.
      Ubiquity and Diversity of Human-Associated Demodex Mites

      research Ubiquity and Diversity of Human-Associated Demodex Mites

      83 citations , August 2014 in “PLoS ONE”
      This study suggests that Demodex mites might universally inhabit adult humans, with a phylogenetic analysis indicating potential undiscovered lineages of the D. brevis species based on geographic differences.
      Hair Loss in Women: Comprehensive Overview and Treatment Options

      research Hair Loss in Women

      81 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”
      This review discusses the classifications, diagnostic methods, and treatment strategies for female pattern hair loss, but reports no clinical results.
      What Causes Hidradenitis Suppurativa?—15 Years After

      research What causes hidradenitis suppurativa ?—15 years after

      78 citations , October 2020 in “Experimental Dermatology”
      This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.