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GlossaryAKT2

gene involved in cell growth and survival signaling

AKT2 is a gene that encodes a protein involved in cell signaling pathways, which regulate processes like cell growth, survival, and metabolism. In the context of hair and alopecia, abnormalities in AKT2 function can affect hair follicle health and contribute to hair loss conditions.

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research Expression of AKT1 Along with AKT2 in Granulosa-Lutein Cells of Hyperandrogenic PCOS Patients

24 citations, March 2017 in “Archives of Gynecology and Obstetrics”

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

19 citations, October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.

research How to Diagnose a Lipodystrophy Syndrome

53 citations, June 2012 in “Annales d'Endocrinologie”

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

research AKT2 Gene Polymorphisms, sRANKL/OPG and Hormone Measurements in Polycystic Ovarian Syndrome Women

January 2017 in “Clinical & medical biochemistry”

Certain gene variations in AKT2 are more common in women with PCOS and are linked to higher levels of specific hormones and symptoms.

research Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos

7 citations, September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

research First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

505 citations, December 2011 in “Journal of clinical oncology”

MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis

106 citations, October 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

A 10 Mb Duplication in Chromosome Band 5q31.3–5q33.1 Associated with Late-Onset Lipodystrophy, Ichthyosis, Epilepsy, and Glomerulonephritis

research A 10 Mb Duplication in Chromosome Band 5q31.3–5q33.1 Associated with Late-Onset Lipodystrophy, Ichthyosis, Epilepsy, and Glomerulonephritis

5 citations, May 2011 in “European Journal of Medical Genetics”

A genetic duplication on chromosome 5 was linked to a woman's unique combination of medical conditions.

research Enzymes

1 citations, November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Four Days of Simulated Shift Work Reduces Insulin Sensitivity in Humans

50 citations, January 2018 in “Acta physiologica”

Working night shifts for four days can lower the body's ability to use insulin, which may increase the risk of type 2 diabetes.

research Genome-Wide Target Enrichment-Aided Chip Design: A 66K SNP Chip for Cashmere Goat

13 citations, August 2017 in “Scientific reports”

Researchers developed a cost-effective 66 K SNP chip for cashmere goats that is accurate and useful for genetic studies.

research FOXO1, TGF-β Regulation and Wound Healing

87 citations, September 2014 in “International Journal of Molecular Sciences”

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations, January 2016 in “Cellular physiology and biochemistry”

Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.

research Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

65 citations, February 2011 in “Molecular cancer therapeutics”

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

research The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

6 citations, May 2020 in “Pharmacology Research & Perspectives”

A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.

research Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo

44 citations, September 2019 in “The EMBO Journal”

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

research Keratins in Health and Cancer: More Than Mere Epithelial Cell Markers

438 citations, October 2010 in “Oncogene”

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

research Genome-Wide Association Studies for Immunoglobulin Concentrations in Colostrum and Serum in Chinese Holstein

September 2020 in “Research Square (Research Square)”

Certain genes influence immunoglobulin levels in Chinese Holstein cows, which can improve calf health.

research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity

70 citations, January 2014 in “International review of cell and molecular biology”

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

research MicroRNA Species in Follicular Fluid Associating With Polycystic Ovary Syndrome and Related Intermediary Phenotypes

50 citations, January 2016 in “The Journal of Clinical Endocrinology and Metabolism”

Certain microRNAs in the fluid around eggs are linked to Polycystic Ovary Syndrome and may help diagnose it.

research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

30 citations, April 2020 in “Stem Cell Research & Therapy”

PI3K/Akt pathway is crucial for hair growth and regeneration.

research Immunologic Findings in Central Centrifugal Cicatricial Alopecia

1 citations, July 2012 in “Nasza Dermatologia Online”

CCCA may be caused by both hair traction and an immune response.

research Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles

27 citations, November 2013 in “Journal of Dermatological Science”

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

research Enzymes

March 2008 in “British Journal of Pharmacology”

Enzymes play crucial roles in metabolism, health, and disease management.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations, January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.