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This study uncovered that bimatoprost, a prostaglandin analog, promotes hair growth by activating hair follicle progenitor cells through two pathways: the PTGFR-MAPK signaling axis and an unexpected IGF1R-PCAD-AKT signaling axis, suggesting new potential targets for treating hair disorders.

This study highlights that topical melatonin formulations have the potential to increase hair density, prolong the hair growth phase, and reduce shedding in adults with alopecia, while generally being safe, though further large-scale randomized trials are needed to confirm its clinical efficacy.

This study found that 5-aminolevulinic acid combined with ferric ammonium citrate stimulated hair follicle growth and induced hair-like structures in human hair follicle models, suggesting its potential as a treatment for hair loss.

In this study, a mouse model with a PIK3CA gain-of-function mutation in Schwann cells revealed unique communication with neighboring cells and a glycolytic shift in peripheral nerves, and early alpelisib treatment significantly improved symptoms, though efficacy declined with delayed administration due to limited drug penetration.

In this study, a silk fibroin hydrogel containing recombinant NT3 was found to promote scar-less wound healing in a mouse skin injury model by enhancing type III collagen expression and inducing hair follicle formation.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

This study reviewed how certain phytochemicals can stimulate hair follicles, promote keratinocyte proliferation, and engage specific signaling pathways like Wnt/β-catenin and AKT, suggesting these natural compounds may offer safer alternatives for promoting hair growth. However, challenges in bioavailability and formulation standardization remain to be addressed.

In this study, 2′‐Fucosyllactose (2′‐FL) administration significantly reduced hair loss and increased hair length and thickness in a testosterone-induced androgenic alopecia mouse model, suggesting potential as a therapeutic agent for AGA.

This study found that mitochondrial fusion regulator Opa1 is crucial for maintaining melanocyte stem cells during the hair follicle cycle in mice, with Opa1 deficiency leading to impaired SCF-KIT signaling, reduced melanocyte populations, and early hair graying.

This study found that Gynostemma pentaphyllum leaf hydrodistillate (GPHD) promoted hair growth in mice similarly to minoxidil and upregulated growth factor expression via the AKT/β-catenin signaling pathway, with damulin B identified as an active component contributing to these effects.

This study observed that a novel extracellular matrix hydrogel made from human fibroblast-derived matrix improved wound healing in animal models, showing significant effects such as hair follicle formation, reduced inflammation, enhanced pro-healing growth factor levels, and interaction with macrophages, compared to traditional collagen hydrogels.

This study suggests that phloroglucinol may enhance anagen signaling and reduce oxidative stress-induced damage in human dermal papilla cells, offering a potential therapy for hair loss.

In this laboratory study, researchers found that a methanol extract of peach kernel improved the growth and viability of human hair follicle dermal papilla cells, suggesting its potential efficacy for hair growth and care through cell proliferation and signaling pathways activation.

This study found that simultaneous inactivation of pRb and p53 genes in mice's epidermis accelerates aggressive squamous cell carcinoma development, highlighting p53 as a key tumor suppressor.

This study found that the simultaneous inactivation of pRb and p53 genes in mouse epidermis accelerated aggressive squamous cell carcinoma development via activation of the epidermal growth factor receptor/Akt pathway.

This study suggests that silibinin enhances signaling pathways related to hair growth in three-dimensional cultured human dermal papilla cells, indicating its potential as a treatment for alopecia.

This study developed an Asian human sebocyte cell line from breast skin tissue that can be used for sebaceous gland biology investigations, showing that Y27632 may promote cell growth through EGFR-CRAF-MEK-ERK and AKT pathways.

This study suggests that silibinin may promote hair growth in 3D-cultured human dermal papilla spheroids by activating the Akt and Wnt/β-catenin signaling pathways.

This review discusses the role of PRP in treating androgenetic alopecia and alopecia areata, but reports no new clinical results and emphasizes the potential of growth factor signaling as a future therapy.

This study found that in mutant NRAS melanoma, MEK inhibitors led to increased AKT signaling and reduced MIG6, a change that may enhance cell migration and invasiveness.

This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.

This study found that Fructus Ligustri Lucidi water extract significantly increased proliferation in human hair dermal papilla cells, potentially promoting hair growth by activating ERK and Akt pathways.

In this study, Fructus Ligustri Lucidi extract was found to promote the proliferation of human hair dermal papilla cells by activating the ERK and Akt pathways.

In this study, low-level light therapy increased the proliferation and activation of dermal papilla cells, which in turn may enhance the growth of outer root sheath keratinocytes, suggesting potential mechanisms for improving hair follicle interaction.

This study found that sandalwood and rose absolute oils significantly accelerated hair regrowth in a shaved mouse model, suggesting their potential for use as hair growth stimulators.

In this study, sandalwood and rose absolute oils were found to accelerate hair regrowth and promote hair follicle development in a mice model over four weeks.

In this study, researchers identified significant differences in lipid composition between grey and black hair follicles in women with type 2 diabetes and healthy controls, suggesting these lipids may contribute to the production of grey hair and may offer targets for anti-grey-hair treatments.

This study investigated the potential mechanisms of Curcuma aeruginosa in treating androgenetic alopecia and identified 66 bioactive compounds interacting with proteins involved in the disorder, suggesting its involvement in hormone response and specific signaling pathways.

This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.

This study mapped potential targets and pathways for baicalin's action in androgenic alopecia, suggesting it may inhibit 5α-reductase and serve as an effective treatment ingredient.