21 citations,
May 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.
17 citations,
February 2019 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
16 citations,
February 2018 in “European Journal of Endocrinology” Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.
14 citations,
September 2015 in “Expert Opinion on Therapeutic Targets” The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
14 citations,
December 2010 in “Seminars in Oncology” Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.
12 citations,
February 2016 in “Biochemical and Biophysical Research Communications” Sulforaphane may help with hair growth by breaking down a hormone that causes hair loss.
11 citations,
February 2016 in “Current Medicinal Chemistry” New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
11 citations,
March 2008 in “Experimental Dermatology” A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.
10 citations,
May 2018 in “Neuropharmacology” Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
8 citations,
April 2019 in “Journal of the Endocrine Society” Postmenopausal women with hyperandrogenism didn't have better metabolic health even after their testosterone levels became normal.
6 citations,
May 2022 in “Aging” Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.
5 citations,
January 2017 in “Endocrinology” Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
3 citations,
June 2021 in “Cosmetics” A mix of sulforaphane, L-menthol, and dexpanthenol could help increase hair growth and reduce hair loss.
1 citations,
January 2019 in “Elsevier eBooks” Neuroactive steroids may affect the risk and treatment of alcohol use disorders.
1 citations,
January 2017 in “Tohoku journal of experimental medicine” A woman's mature cystic teratoma caused her virilization by producing testosterone.
1 citations,
September 2012 in “Expert Review of Endocrinology & Metabolism” Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.
A thorough diagnostic process and teamwork are crucial for managing complex hyperandrogenism in postmenopausal women.
December 2023 in “Frontiers in endocrinology” Excess androgens may cause PCOS, not just be a symptom.
October 2023 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Hyperandrogenism increases heart disease risk in premenopausal women, but this risk is linked to obesity in postmenopausal women.
October 2023 in “Frontiers in endocrinology” Effective PCOS treatments require targeting specific signaling pathways.
June 2023 in “Journal of multidisciplinary sciences” PCOS may increase the risk of certain cancers.
June 2023 in “Journal of multidisciplinary sciences (Online)” PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.
July 2017 in “Contemporary Endocrinology” The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.
November 2009 in “Medical & surgical dermatology” The document concludes that Borrelia afzelii causes a skin condition in France, a gene is linked to hair loss in Caucasian women, and various genetic mutations affect skin diseases.
February 2008 in “Medical & surgical dermatology” Some treatments like topical oxygen and stem cells show promise for wound healing and hair growth, but evidence for modern dressings over traditional ones is limited.
57 citations,
April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology” Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.
22 citations,
January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” A new method accurately measures nine specific hormones in human blood.
January 2020 in “Journal of St. Marianna University” Human placenta extract may promote hair growth by affecting certain lipid compounds.
131 citations,
September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
56 citations,
July 2014 in “PloS one” SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.