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This study found that Pep-1-mediated mitochondrial transplantation was as effective as PRP therapy in restoring hair loss related to aging in mice, with distinct improvements in hair and skin-related measures.

This study found that Si Jun Zi Tang may have anti-aging effects in mice, linked to inhibition of the PI3K-AKT and P38 MAPK signaling pathways.

This review highlights the benefits of using natural herbal extracts, containing compounds like polyphenols and flavonoids, in anti-aging skincare formulations, suggesting they offer moisturizing, antioxidant, and rejuvenating effects, especially when incorporated with nano-formulations for enhanced efficacy.

This study examined aging hair follicle stem cells in mice and found that inflammation reduction in dermal white adipose tissue can stimulate regenerative behavior, highlighting its role in hair follicle aging.

This study found that hair analysis is an effective non-invasive method for assessing metabolic fluctuations, showing stable advanced glycation end products levels that correlate with age and differ significantly between diabetic and non-diabetic rats.

Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.

This case report from the University of Alabama, Birmingham describes a rare paradoxical reaction of increased agitation and hyperactivity in a patient with schizoaffective disorder treated with divalproex sodium.

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

This review discusses the fundamental hallmarks of aging as they relate to skin aging and highlights the prominent roles of oxidative damage and the extracellular matrix in photoaging, reporting no new results.

In this study, researchers found that Elastic Net DNA methylation clocks are not accurate for distinguishing between individuals or identifying health markers, but measuring biological "noise" in stable cytosines may serve as a potential biomarker of aging and disease.

This review discusses how aging affects hair follicle stem cells and their environment, contributing to hair loss, and explores strategies to promote hair regrowth, but reports no new results.

This study utilized UK Biobank data to identify genetic factors associated with self-perceived facial aging, highlighting significant roles for skin pigmentation, immune pathways, and extracellular matrix genes.

This study found that in poodles, perifollicular changes in the hair follicle glassy membrane are not always linked to calcium deposition.

This review found that lip aging differs significantly from facial aging and suggests focusing on distinct anti-aging strategies for lips, considering gender differences and unique physiological characteristics.

The study emphasizes that telomere shortening is identified as the sole cause of aging among the twelve hallmarks and suggests that increasing telomere and rDNA array length in adult stem cells might effectively reverse aging and extend lifespan.

Skin aging reflects overall body aging and can indicate internal health conditions.

This review discusses factors affecting hair aging, such as inflammation and UV exposure, and examines potential anti-aging benefits of antioxidants and nutraceuticals for hair, but reports no new clinical results.

Aging weakens sweat glands due to reduced support from immune cells, but treatments may help restore function.

This study presented a reproducibility package supporting an exploratory secondary analysis of miRNA dysregulation and aging-related target enrichment in female pattern hair loss, based on a comparison of three scalp samples from affected women to five healthy controls using public dataset GSE106780.

In this study, researchers conducted an exploratory re-analysis of miRNA dysregulation and aging-related target enrichment using publicly available data on female pattern hair loss, comparing 3 FPHL scalp samples to 5 healthy female controls, and emphasized that the findings are preliminary and require further validation.

This review highlights the complex interplay between intrinsic and extrinsic factors influencing skin aging, emphasizing the need for advanced human-specific models to study aging mechanisms and develop new therapies.

This review provides a comprehensive synthesis of skin aging research, highlighting the interplay of genetic and environmental factors, cellular mechanisms, and advances in diagnostic and therapeutic strategies, while also addressing current debates and future directions in the anti-aging field.

This study highlights the critical role of mitochondria in skin aging and wound repair, suggesting that targeted interventions such as antioxidants, NAD⁺ boosters, and NRF2-based therapies may enhance mitochondrial function and improve cutaneous health.

In this study, researchers found that cochlear hair cell function declined with age in CBA/CaJ mice starting at 10 months, before detectable hearing loss, and was marked by a decrease in cell size and BK channel currents, without effect on MET currents.

This review examines the potential of alpha-ketoglutaric acid as an anti-aging agent and for treating age-related diseases, emphasizing its metabolic, immune, and cosmetic benefits but reports no new clinical trials.

In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.

This study developed a deep learning-based tool to quantify individual hair fibers in mice, revealing distinct hair phenotypes linked to hormonal, genetic, and age-related factors, and suggesting its potential for new diagnostic methods through hair analysis.

This review discusses the potential anti-aging effects of adipose-derived stem cells on facial skin, such as reducing wrinkles, whitening skin, and promoting hair growth, but provides no new clinical results.

This study presents a new long-term 3D skin model using cells from mature donor skin, showing significant features of skin aging, such as decreased cellular proliferation and hyaluronan content.