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This study reports that a newly developed polyherbal phospholipid complex cream containing Citrus auranticum and Glycyrrhiza glabra extracts improved polyphenol retention in the skin, suggesting potential as an anti-aging cosmeceutical.

This review examines the potential mechanisms by which stem cell-derived cell-free therapy may prevent skin aging, highlighting various molecular targets and pathways involved in regeneration, oxidative stress regulation, ECM preservation, cell activity modulation, and inflammation.

This study found that patients with myotonic dystrophy types 1 and 2 often exhibit skin abnormalities, which correlate with genotype severity and serum vitamin D levels, and suggest premature aging.

This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.

In this mouse study, researchers reported that sequential monopolar-bipolar radiofrequency irradiation significantly improved skin quality by increasing collagen density, elastin fiber expression, and fibroblast differentiation more than monopolar RF treatment alone.

This study found that taking oral FKH supplements for 90 days improved facial skin, hair, and nail appearance, and highlighted the role of free L-amino acids as potentially beneficial beyond their protein-building functions.

In a study on mice, cow placenta extract showed strong antioxidant activities and reduced collagen damage, suggesting it could help delay skin aging caused by D-galactose.

This study found that increased mRNA expression of the Ectodysplasin-A2-Receptor, observed across multiple species and tissues, may exacerbate inflammation during aging, suggesting potential benefits of blocking EDA2R/EDA-A2 signaling.

This study found that bergamot and boxthorn extract significantly improved skin antioxidant activity and collagen content while promoting hair growth in mice.

This study observed that women with cicatricial hair loss had an increased risk of hypertension, which may share overlapping biological origins.

This systematic review suggests that human placental extracts may offer therapeutic benefits for non-communicable diseases such as liver pathologies and metabolic disorders, but larger trials are needed to confirm efficacy and understand molecular pathways.

This paper provides an auditable companion package for their exploratory re-analysis of miRNA dysregulation and target enrichment in female pattern hair loss cases, focusing on candidate-level results from a public dataset comparison between affected individuals and healthy controls.

In this study, researchers conducted an exploratory re-analysis of miRNA dysregulation and aging-related target enrichment in female pattern hair loss using data from public GEO dataset GSE106780. The findings are preliminary and should be interpreted as candidate-level results due to the small sample size.

This review analyzes PDRN's molecular mechanisms and therapeutic applications in anti-aging dermatology but reports no new clinical results, highlighting the need for more standardized protocols and long-term evaluations.

The supplement may improve hair growth and skin health with some mild risks.

This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.

This study found that astaxanthin effectively protected human dermal papillae cells from oxidative stress induced by hydrogen peroxide, reducing the percentage of cells expressing a stress marker significantly, suggesting potential benefits for hair loss treatment related to reactive oxygen species.

In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

This study concluded that the Mexican primary healthcare sector requires more comprehensive training on the physiological changes and common skin diseases prevalent among the elderly population.

This review discusses how sex hormone levels and local steroid synthesis influence gender differences in aging skin, reporting no new clinical results.

This book review in the Archives of Facial Plastic Surgery discusses "Comprehensive Facial Rejuvenation: A Practical and Systematic Guide to Surgical Management of the Aging Face" but does not provide new clinical research results.

This study identified a crucial role for epidermal Pgc-1α in regulating NAD+ signaling and influencing skin repair, with its dysfunction contributing to age-related wound healing defects.

This study found that platelet-rich plasma treatment significantly improved erectile function and restored neural structures in aged rats with erectile dysfunction, suggesting potential benefits for geriatric patients.

In this study on C57BL/6 mice, researchers found that cadmium chloride exposure led to metabolic disruption, accelerated skin aging, and impaired hair regeneration, with more severe effects observed at higher doses.

This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.

This study suggests that the activation of box A in mesenchymal cell models may enhance stem cell properties, increasing the expression of stemness markers like OCT4, NANOG, and SOX2.

This review reports that collagen as a nutraceutical shows promising results for improving skin health in estrogen-deficient women, but more research is needed for scalp hair, nail health, and optimal dosing of curcumin and glutathione.

This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.

This source critically examines Bruce Ames's influential contributions to biochemistry, particularly his theories on oxidative stress and mitochondrial DNA damage in aging, while acknowledging current challenges to his work and highlighting his lasting impact on the fields of mutagen screening and public health.