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This study found that in the dorsal horn's lamina III, most afferent boutons form synapses with presynaptic boutons immunoreactive for GABA and/or glycine, influencing sensory pathways.

In this study, researchers observed that dorsal horn cells in fetal sheep begin responding to natural cutaneous stimulation by mid-gestation, coinciding with the initial innervation of the skin.

Aδ-LTMRs have complex synapses with glycine, while Aβ-LTMRs have simpler ones.

This study found that presynaptic inhibition of Aαβ cutaneous primary afferents in cats is mostly mediated by GABAergic interneurons that also contain glycine.

This study found that human C-tactile afferents respond to hair deflection, suggesting a functionally relevant anatomical relationship to hair follicles similar to that observed in mice.

This study reported that novel kainate derivatives, especially ZCZ90, maintained potency in affecting proprioceptive sensory organ firing, aiding future receptor studies for potential treatment innovations.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

This study suggests that hair-follicle afferent axons can be presynaptically inhibited by boutons containing the enzyme glutamic acid decarboxylase, which is linked to the synthesis of γ-aminobutyric acid.

This study found no evidence supporting the hypothesis that Aβ afferents sprout into the superficial laminas of the spinal cord after nerve injury in rats.

This study observed that electrical stimulation of specific mechanoreceptive afferents in the orofacial region can evoke sensations consistent with their response properties, while others may require multiple afferents to access perceptual levels.

This study found that the spinal projection of afferents innervating slowly adapting mechanoreceptors had a greater rostrocaudal extent and number of boutons compared to those innervating rapidly adapting mechanoreceptors.

Using synchrotron X-ray imaging, this study mapped the complex innervation of male rat vibrissa follicles, revealing distinct types of myelinated afferent neurons and patterns of axonal organization that may inform sensory processing in the brainstem.

This study examined the sensory innervation of hair follicles in the furry skin of rat hindlimbs, finding significant differences among hair types in their innervation patterns and densities.

This study revealed the complex three-dimensional innervation of touch domes in cat forepaw skin, highlighting the extensive branching and unmyelinated endings associated with Merkel cell–axon complexes.

This study found that feminizing hormone therapy increased GFR in transgender individuals assigned male at birth, suggesting an effect of sex hormones on kidney hemodynamics, while masculinizing therapy showed a slight, nonsignificant decrease in GFR.

This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.

This study estimates that approximately 230,000 tactile afferent fibers innervate the human body's skin, with varying densities across different regions correlating with spatial acuity and hair follicle density.

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

This review summarizes a 15-year collaboration on the role of synaptic-like vesicles in mechanosensory nerve terminals and suggests potential therapeutic implications for conditions like hypertension and muscle spasticity.

This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.

This review discusses advances in understanding tickling sensations and proposes that knismesis hypersensitivity in autism spectrum disorder may be due to impaired sensory integration.

In this study, researchers found that the glabrous skin of the rat forelimb contains sparse Meissner corpuscles and Merkel complexes, with more slowly adapting afferents in the palm and rapidly adapting afferents in the digit extremity.

This study observed that innervation of the mystacial pad in rats by fine-caliber axons is more extensive and complex than previously described, with distinct differences in labeling patterns depending on the tracer and survival time.

The cuneate nucleus has two main neuron types: relay neurons and interneurons.

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

This study found that glycinergic synapses in the rat spinal cord are predominantly associated with gephyrin, though gephyrin may also be present at non-glycinergic synapses.

In this study, researchers used synchrotron X-ray imaging to examine rat vibrissa follicles, finding that despite variations in vibrissa length and follicle size, certain sensory structures remain consistent, suggesting specialized roles in sensory processing depending on the vibrissa type.

This study demonstrates that locally synthesized estrogen and androgen neurosteroids play opposite roles in long-term synaptic changes in male rats' medial vestibular nucleus, with testosterone-dihydrotestosterone mediating long-term depression and 17β-estradiol mediating long-term potentiation.

This study found that SK2 channels in sensory terminals of rat muscle spindles and hair follicles may play a crucial role in modulating mechanosensory transduction by influencing receptor potentials through Ca2+-activated K+ currents.