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Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

The document explains various skin conditions and their treatments.

New drugs for Alzheimer's and rheumatoid arthritis advanced, a Zika vaccine is in development, and there were business deals in anesthesia and oncology.

The document concludes that accurate diagnosis and management of PCOS are crucial due to its associated health risks.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

No single treatment is consistently effective for alopecia areata, and more research is needed.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Testosterone may slow down wound healing and increase inflammation.

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Pregnant women often experience skin and hair changes, with over half getting stretch marks and pigment changes, and should be cautious with cosmetic procedures due to potential risks.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.