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Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

A man with X-ALD improved after treatment, highlighting the need to consider X-ALD in similar patients and test their relatives.

A 21-year-old male with a rare genetic disorder experienced sudden hair loss and high DHEAS levels, likely due to a condition similar to PCOS, usually seen in women.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

A 68-year-old woman developed male traits due to a tumor in her ovary, which was removed, returning her hormone levels to normal.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

More research is needed to understand how testosterone is maintained in adult males.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

LC-MS/MS is more reliable than immunoassays for diagnosing 21-hydroxylase deficiency.

Polycystic ovary syndrome causes high male hormone levels, leading to symptoms like excess hair, acne, and fertility problems.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Chromosomal differences affect how muscle cells respond to testosterone.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.

Polycystic Ovary Syndrome can cause hair loss and skin issues, and early treatment is important for preventing complications.

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

The study suggests certain ACE gene variations are more common in women with PCOS and may be linked to increased insulin resistance.

Spironolactone is a low-cost, effective, and generally safe treatment for various skin conditions related to hormones.

Finger length ratio may indicate male hair loss.

Women with PCOS often have sexual problems, and treating these issues early can improve satisfaction and reduce healthcare costs.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

Hormonal therapy is effective for treating acne in adult women, especially with signs of high androgen levels.