research Clinical Applications of Antiandrogens
Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.
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research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride
Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
research Polycystic Ovary Syndrome (PCOS): An Inflammatory, Systemic, Lifestyle Endocrinopathy
PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.
research Peripheral Androgens And The Role Of Androstanediol Glucuronide
Androstanediol glucuronide is a reliable marker for hirsutism in women.
research Antiandrogen Treatment of Polycystic Ovary Syndrome
Antiandrogen treatments combined with oral contraceptives can help manage hair growth and hair loss in women with PCOS.
research Early Postnatal Allopregnanolone Levels Alteration and Adult Behavioral Disruption in Rats: Implications for Drug Abuse
Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
research Glossary
research Androgenetic Alopecia: Treatments and Efficacy
Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.
research Alopecia: Unapproved Treatments or Indications
Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
research Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid
High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.
research Dihydrotestosterone Induces p27 Degradation via Direct Binding with SKP2 in Ovarian and Breast Cancer
Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.
research Treatment of Hyperandrogenism in Polycystic Ovary Syndrome
Hormonal therapies are effective for managing hair and skin symptoms in women with PCOS.
research Vitamin D and Skin: A Review and Update
Vitamin D is important for skin health and can help treat and prevent various skin conditions.
research Hereditary, Congenital, and Acquired Alopecias
Different types of hair loss in dogs and cats have various causes and treatments, with outcomes ranging from good to uncertain.
research Hereditary, Congenital, And Acquired Alopecias
Alopecia in animals can be hereditary, congenital, or acquired, with treatments and outcomes varying widely.
research Estrogens and Aging Skin
Estrogen therapy can reduce skin aging but has cancer risks.
research Hair Regrowth
Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.
research Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells
Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.
research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor
New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.
research Expression and Function of Nuclear Receptor Co-Activator 4: Evidence of a Potential Role Independent of Co-Activator Activity
NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.
research Expression of Steroidogenic Enzymes in Human Sebaceous Glands
Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.
research Hormonal Therapy in Dermatology
Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.
research Diet and Acne
Diet changes can help reduce acne by limiting certain hormones.
research Contraceptive Use in Acne
Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.
research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites
The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
research Cyproterone Acetate: A Genotoxic Carcinogen?
Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.
research Hirsutism
Excessive hair growth in women, often from high androgen levels, is usually caused by PCOS, and can be treated with hair removal, medication, and possibly weight loss.
research Male Androgenetic Alopecia
DHT, a testosterone byproduct, causes male pattern baldness.
research Androgen Profiling by Liquid Chromatography–Tandem Mass Spectrometry in Healthy Normal-Weight Ovulatory and Anovulatory Late Adolescent and Young Women
The research found that anovulatory young women have higher androgen and hormone levels than those who ovulate, suggesting immature hormonal regulation rather than a specific condition.
research The Safety of 52 Weeks of Oral DHEA Therapy for Postmenopausal Women
Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.