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The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Baicalin may help reduce excessive male hormone levels in PCOS.

Hair color is determined by melanin produced and transferred in hair follicles.

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Metformin improves quality of life, emotional health, and sex life in women with polycystic ovary syndrome.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Sarcoidosis is more common and severe in Black patients than in Caucasians, requiring early diagnosis and treatment.

Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.

Testosterone therapy may slightly increase sexual desire in women with HSDD but lacks broad recommendation due to safety concerns and limited approval.

Recognizing and managing central sensitization and stress is crucial for treating chronic pain.

Camellia japonica extract may improve scalp health and promote hair growth.

People with hair loss conditions may also have thyroid disorders, but more research is needed to understand the connection.

Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

A young Russian girl with Meier-Gorlin syndrome has two new mutations in the CDC6 gene.

Glucocorticoid treatment in lupus can cause oral lesions, which need early diagnosis and comprehensive care.

Auriculotherapy and Aslagh capsules are as effective as metformin for treating PCOS symptoms, with auriculotherapy slightly better for reducing hair growth.

A balanced diet with proteins, vitamins, and minerals is crucial for managing skin disorders.

Monkey hair cortisol levels are not affected by how fast their hair grows.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

The dog died from myxedema coma linked to severe atherosclerosis and thyroid issues.

A woman with lupus had blood cell destruction, treated successfully with medication.

IMTA can help regrow hair in severe alopecia areata when JAK inhibitors don't work well.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

An 11-year-old child with total hair loss may have a genetic autoimmune disease, and the outlook for hair regrowth is not good.