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The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

PCOS is a common hormonal disorder in women, treated with lifestyle changes and medications like hormonal contraceptives and metformin.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

DHT, a testosterone byproduct, causes male pattern baldness.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Hormonal therapies are safe and effective for treating adult women's acne.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.