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Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

Minoxidil helps regrow hair in female pattern hair loss, but more research needed for other treatments.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.

Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Most women with Polycystic Ovary Syndrome (PCOS) have skin issues like excessive hair, acne, or hair loss. Hormone imbalances are common, and age, certain hormones, and hormone ratios can predict acne. Obesity, infertility, and high cholesterol are also common in these women.

PCOS affects fertility and is linked to obesity and menstrual irregularities; lifestyle changes are recommended for treatment.

Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.

Menopause causes dry skin, wrinkles, and hair changes, with hormone therapy helping but not recommended just for these issues.

Testosterone affects stress hormone levels differently in adolescent and adult male rats.

New genes and pathways are important for testosterone production and male sexual development.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Women with congenital adrenal hyperplasia (CAH) have more sexual function issues than those with polycystic ovary syndrome (PCOS), but physical activity can improve sexual functioning in all women.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Finasteride may cause sexual dysfunction by reducing epinephrine levels.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Menopausal women have higher androgen levels, which can cause symptoms like facial hair growth and low sexual desire.

Some women with excess hair growth have a hormone condition that can't be diagnosed by blood or urine tests alone.

Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.