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This study reported that compound 16 (olean-12-en-3beta-ol, cinnamate) from Merremia peltata showed potential as an androgen receptor antagonist, suggesting it may benefit alopecia treatment based on molecular docking and ADME-Tox predictions.

In this study, quercetin and kaempferol, two plant-derived flavonoids, showed stronger binding affinities to JAK3 kinase and moderate binding to 5-alpha reductase type 2, suggesting their potential as natural treatments for androgenetic alopecia, with quercetin demonstrating suitable properties for topical application.

This study used molecular docking to analyze the binding affinities of quercetin and kaempferol, plant-derived flavonoids, showing they have promising interaction profiles with JAK3 kinase and moderate binding with 5-alpha reductase type 2, suggesting potential as topical treatments for androgenetic alopecia.

This study found that isorhamnetin, a compound from the Rampai plant, showed a lower affinity energy in molecular docking tests compared to Minoxidil, indicating potential as an androgen receptor antagonist for alopecia therapy in silico, with favorable pharmacokinetic characteristics in ADME-Tox predictions.

This study found that the chemical composition and biological activity of Platycladus orientalis fruit extracts varied with the extraction method, revealing potent antioxidant and enzyme inhibitory properties, particularly in the n-hexane extract, which suggests potential applications for managing dysregulated enzyme conditions.

This review suggests that the compound DRDE-07, originally a sulphur-mustard countermeasure candidate, could potentially be repurposed for skin protection due to its compatibility with pathways involved in oxidative stress and inflammation, though further experimental study is needed to confirm its therapeutic applicability in dermatology.

This study conducted molecular docking and ADME property analysis on 144 newly designed isatin analogs, suggesting they exhibit lead-like properties for targeting EGFR enzymes.

This study suggests that compounds from turmeric and bitter have potential antiviral activity against the influenza A virus by inhibiting the polymerase PA-PB1, warranting further experimental verification.

In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.

This study found that among patients hospitalized with COVID-19 in East London, ongoing symptoms were common, with 70% experiencing issues like fatigue and breathlessness, impacting their return to work.

In this study of childhood skin diseases from 2014 to 2017, eczema was the most common diagnosis, and adolescents frequently presented with acne vulgaris, aligning with existing literature patterns but noting more diagnoses and hair disease visits.

In this original study, researchers documented 121 COVID-19 cases with a wide range of mucocutaneous manifestations, some linked to internal organ damage and others to new vaccine-associated dermatoses, emphasizing the importance of rapid diagnosis to prevent potentially life-threatening systemic events.

In this case report, a 7-month-old girl with suspected acrodermatitis enteropathica and severe dermatitis experienced a tragic outcome despite zinc treatment, highlighting the challenges of diagnosing and managing this rare genetic disorder.

This study found that 30.5% of patients at an outpatient clinic reported using complementary and alternative medicine, with many believing in its positive effects despite limited knowledge of potential side effects.

Among young male patients in a cardiac care setting, this study found that 54.4% had androgenetic alopecia, supporting the hypothesis that vertex pattern baldness could indicate a higher risk of cardiovascular events. Further research is needed to confirm these findings.

This study investigates the potential of onion extract as a treatment for androgenetic alopecia by using in silico and ADME/T analyses to examine how active compounds from onions interact with the 5-alpha-reductase enzyme.

This study found that the Turkish version of the Multidimensional Assessment of Interoceptive Awareness-2 Scale is valid and reliable for use with Turkish dermatology patients.

This study used a multi-layer in silico framework to evaluate Korean herbal compounds for androgenetic alopecia, identifying Biochanin A, Saponin Re, and Emodin as potential topical candidates with distinct safety and affinity profiles, although these findings remain purely computational without experimental validation.

This study evaluated Korean herbal compounds in silico and identified Biochanin A, Saponin Re, and Emodin as potential topical treatments for androgenetic alopecia, each with specific safety and efficacy considerations.

In this study, in silico analysis identified Saponin Re and Emodin as promising candidates for topical treatment of androgenetic alopecia, with Biochanin A having the most favorable safety profile among the tested compounds.

This study conducted an in silico evaluation of Korean herbal compounds against key targets involved in androgenetic alopecia, finding Biochanin A, Saponin Re, and Emodin as promising candidates for topical treatments, but highlighting safety and topical formulation challenges.

This study identified Saponin Re and Emodin as top candidates for treating androgenetic alopecia, suggesting future research in dermal papilla cell cultures and scalp organoids despite safety concerns.

This review highlights the significant impact of finasteride on the approach to androgenetic alopecia and hair transplantation and reports no new clinical results.

This study discovered a potential new 5α-reductase type II inhibitor with higher predicted activity than finasteride, suggesting it as a promising candidate for treating benign prostatic hyperplasia.

This study found that bufotalinin, derived from Merremia peltata leaves, may enhance hair growth by acting as a potential androgen receptor antagonist in rabbits.

This study found that the compound (+)–Marmesin from Petroselinum crispum showed potential as an anti-alopecia agent by demonstrating better binding to androgen receptors than minoxidil, though not surpassing native ligands.

This study conducted an in silico evaluation and found that berberine displayed better binding interactions with the 5α-reductase enzyme and TGF-β2 compared to minoxidil, suggesting its potential as a therapeutic agent for androgenetic alopecia.

This study conducted virtual simulations and ADME/T analysis on pumpkin seed compounds to evaluate their interactions with the 5-alpha-reductase enzyme, potentially supporting their use in treating androgenetic alopecia.

This study observed that males aged 60 to 79 were admitted and died from COVID-19 more frequently than females, and Latin Americans were more often admitted to the ICU.

In this study, Almet et al. (2023) compiled integrated single-cell RNA sequencing data from multiple mouse datasets to investigate how fibroblasts evolve during wound healing by examining changes in the extracellular matrix and signaling pathways.